{"id":29845,"date":"2018-03-09T09:23:09","date_gmt":"2018-03-09T09:23:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-y-caracterizacion-de-una-formulacion-de-microesferas-para-administracion-parenteral-del-factor-de-crecimiento-insula%c2%adnico-tipo-1-humano-recombinante-rhigf-i\/"},"modified":"2018-03-09T09:23:09","modified_gmt":"2018-03-09T09:23:09","slug":"desarrollo-y-caracterizacion-de-una-formulacion-de-microesferas-para-administracion-parenteral-del-factor-de-crecimiento-insula%c2%adnico-tipo-1-humano-recombinante-rhigf-i","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-y-caracterizacion-de-una-formulacion-de-microesferas-para-administracion-parenteral-del-factor-de-crecimiento-insula%c2%adnico-tipo-1-humano-recombinante-rhigf-i\/","title":{"rendered":"Desarrollo y caracterizaci\u00f3n de una formulaci\u00f3n de microesferas para administraci\u00f3n parenteral del factor de crecimiento insul\u00ednico tipo-1 humano recombinante (rhigf-i)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Celia Carrascosa Martinez <\/strong><\/h2>\n<p>El objetivo de esta tesis doctoral es el desarrollo de una formulaci\u00f3n que permita la liberaci\u00f3n sostenida del factor de crecimiento insul\u00ednico tipo-i humano recombinante (rhigf-i) con el fin de permitir su empleo en el tratamiento eficaz de enfermedades neurodegenerativas. Para ello se procedi\u00f3 a la revisi\u00f3n bibliogr\u00e1fica de la actividad farmacol\u00f3gica y comportamiento biofarmac\u00e9utico y farmacocin\u00e9tico del rhigf-i, as\u00ed como de los sistemas de administraci\u00f3n de rhigf-i existentes hasta el momento. A partir de la informaci\u00f3n recopilada, se propueso el desarrollo de una formulaci\u00f3n de microesferas para administraci\u00f3n subcut\u00e1nea, por presentar unas buenas caracter\u00edsticas para la liberaci\u00f3n controlada de este factor de crecimiento.  una vez desarrollada, la formulaci\u00f3n de microesferas fue caracterizada y evaluada in vitro. Los requerimientos de esterilidad que implica la administraci\u00f3n parenteral nos llevaron a evaluar la utilidad de la radiaci\u00f3n gamma como m\u00e9todo de esterilizaci\u00f3n terminal del sistema. A continuaci\u00f3n se llevo a cabo la caracterizaci\u00f3n in vivo de la formulaci\u00f3n, realizandose el estudio farmacocin\u00e9tico de la formulaci\u00f3n en dos especies animales. Finalmente, la eficacia terap\u00e9utica de las microesferas de rhigf-i fue evaluada en el tratamiento de ratones pcd (purkinje cell degeneration), modelo animal de ataxia cerebelosa hereditaria, enfermedad neurodegenerativa cr\u00f3nica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo y caracterizaci\u00f3n de una formulaci\u00f3n de microesferas para administraci\u00f3n parenteral del factor de crecimiento insul\u00ednico tipo-1 humano recombinante (rhigf-i)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo y caracterizaci\u00f3n de una formulaci\u00f3n de microesferas para administraci\u00f3n parenteral del factor de crecimiento insul\u00ednico tipo-1 humano recombinante (rhigf-i) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Celia Carrascosa Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/04\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Jose Torrado Duran<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Lastres garcia <\/li>\n<li> Mart\u00edn carmona m. antonia (vocal)<\/li>\n<li>ignacio Torres aleman (vocal)<\/li>\n<li>Mar\u00eda bego\u00f1a Seijo rey (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Celia Carrascosa Martinez El objetivo de esta tesis doctoral es el desarrollo de una formulaci\u00f3n que permita [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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