{"id":29851,"date":"2018-03-09T09:23:10","date_gmt":"2018-03-09T09:23:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacocinetica-farmacodinamia-de-lerisetron-y-sus-metabolitos-tras-administracion-intravenosa-y-percutanea-en-la-rata\/"},"modified":"2018-03-09T09:23:10","modified_gmt":"2018-03-09T09:23:10","slug":"farmacocinetica-farmacodinamia-de-lerisetron-y-sus-metabolitos-tras-administracion-intravenosa-y-percutanea-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/farmacocinetica-farmacodinamia-de-lerisetron-y-sus-metabolitos-tras-administracion-intravenosa-y-percutanea-en-la-rata\/","title":{"rendered":"Farmacocin\u00e9tica-farmacodinamia de lerisetr\u00f3n y sus metabolitos tras administraci\u00f3n intravenosa y percut\u00e1nea en la rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> F\u00e1tima Ortega Muro <\/strong><\/h2>\n<p>Lerisetron es un nuevo f\u00e1rmaco antagonista de los receptores 5-ht3 y es utilizado como antiem\u00e9tico en el tratamiento de los v\u00f3mitos inducidos por f\u00e1rmacos citot\u00f3xicos.  en estudios previos, realizados con lerisetr\u00f3n tras administraci\u00f3n intravenosa en ratas, se observ\u00f3 que \u00e9ste mostraba un elevado volumen de distribuci\u00f3n y un elevado aclaramiento plasm\u00e1tico, lo que se traduce en una vida media de eliminaci\u00f3n corta. Otros estudios parec\u00edan sugerir que lerisetr\u00f3n se metabolizaba ampliamente y que alguno de sus metabolitos pod\u00eda presentar actividad farmacol\u00f3gica, concretamente el matabolito hidroxilado en la posici\u00f3n 6 de la estructura qu\u00edmica de lerisetr\u00f3n, el metabolito l6-oh.  por lo tanto, en el presente trabajo de tesis doctoral se realiz\u00f3, en primer lugar, una b\u00fasqueda cualitativa en plasma y orina de rata, tras administraci\u00f3n intravenosa de lerisetr\u00f3n en ratas sprague-dawley, del metabolito l6-oh y de otros posibles metabolitos de lerisetr\u00f3n. Para ello, se emple\u00f3 un sistema de cromatograf\u00eda l\u00edquida de alta resoluci\u00f3n acoplada a un espectr\u00f3metro de masa lcq (hplc-ms). Una vez identificado el metabolito l6-oh, se caracteriz\u00f3 su cin\u00e9tica (tras su administraci\u00f3n intravenosa a la rata) y su dinamia (mediante la medida del efecto a trav\u00e9s de la inhibici\u00f3n del reflejo de von bezold-jarish en la rata). Se dise\u00f1\u00f3 adem\u00e1s un modelo matem\u00e1tico integrado para caracterizar el comportamiento cin\u00e9tico de lerisetr\u00f3n y el metabolito l6-oh generado tras administraci\u00f3n intravenosa de lerisetr\u00f3n. Esta caracterizaci\u00f3n permiti\u00f3 evaluar la aportaci\u00f3n del metabolito l6-oh al efecto global de lerisetr\u00f3n.  finalmente, se realiz\u00f3 un esudio de absorci\u00f3n percut\u00e1nea de lerisetr\u00f3n en la rata como v\u00eda alternativa de administraci\u00f3n, ya que por esta v\u00eda se pueden alcanzar niveles plasm\u00e1ticos m\u00e1s duraderos en el tiempo que prolonguen los efectos farmacol\u00f3gicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacocin\u00e9tica-farmacodinamia de lerisetr\u00f3n y sus metabolitos tras administraci\u00f3n intravenosa y percut\u00e1nea en la rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacocin\u00e9tica-farmacodinamia de lerisetr\u00f3n y sus metabolitos tras administraci\u00f3n intravenosa y percut\u00e1nea en la rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 F\u00e1tima Ortega Muro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/04\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosario Calvo Duo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Rodr\u00edguez sasiain Jos\u00e9 Miguel <\/li>\n<li>esther Dominguez perez (vocal)<\/li>\n<li>julio Benitez rodriguez (vocal)<\/li>\n<li>aurelio Orjales venero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de F\u00e1tima Ortega Muro Lerisetron es un nuevo f\u00e1rmaco antagonista de los receptores 5-ht3 y es utilizado como [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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