{"id":29871,"date":"2018-03-09T09:23:12","date_gmt":"2018-03-09T09:23:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-del-transporte-de-glucosa-por-oxido-na%c2%adtrico-en-celulas-neurales\/"},"modified":"2018-03-09T09:23:12","modified_gmt":"2018-03-09T09:23:12","slug":"regulacion-del-transporte-de-glucosa-por-oxido-na%c2%adtrico-en-celulas-neurales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/regulacion-del-transporte-de-glucosa-por-oxido-na%c2%adtrico-en-celulas-neurales\/","title":{"rendered":"Regulaci\u00f3n del transporte de glucosa por \u00f3xido n\u00edtrico en c\u00e9lulas neurales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pilar Cidad Velasco <\/strong><\/h2>\n<p>El tratamiento de los astrocitos con lipopolisac\u00e1rido (lps) promueve la expresi\u00f3n transcripcional del transportador de glucosa neuronal glut3, efectos que se acompa\u00f1a de un aumento en la velocidad de captaci\u00f3n de glucosa. para estudiar si glut3 es responsable del aumento de captaci\u00f3n de glucosa provocado por el \u00f3xido n\u00edtrico (no), expresamos, en astrocitos y en la l\u00ednea celular derivada de ri\u00f1\u00f3n humano hek293t, un pl\u00e1smido que codifica una prote\u00edna de fusi\u00f3n del transportador glut3, unido por su extremo carboxilo a la prote\u00edna fluoresecente verde. El transportador se localiza preferentemente en membrana plasm\u00e1tica de forma que las c\u00e9lulas muestran una mayor actividad transportadora as\u00ed como una mayor protecci\u00f3n frente a la muerte por apoptosis provocada por bajas concentraciones de glucosa. La inhibici\u00f3n de la cadena respiratoria mitocondrial por no provoca un r\u00e1pido aumento de la velocidad de captaci\u00f3n de glucosa mediado por glut3, que es independiente de gmp c\u00edclico y que no implica translocaci\u00f3n de transportadores a la membrana plasm\u00e1tica. Adem\u00e1s el silenciamiento del sensor de la carga energ\u00e9tica celular, la prote\u00edna quinasa dependiente de amp (ampk) mediante la tecnolog\u00eda del rna de interferencia, dda lugar a c\u00e9lulas que no responden al \u00f3xido n\u00edtrico estimulando la captaci\u00f3n de glucosa. Por lo tanto el no, v\u00eda ampk, puede tener un efecto citoprotector contra la hipoglucemia a trav\u00e9s de la estimulaci\u00f3n de la captaci\u00f3n de glucosa por glut3.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n del transporte de glucosa por \u00f3xido n\u00edtrico en c\u00e9lulas neurales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n del transporte de glucosa por \u00f3xido n\u00edtrico en c\u00e9lulas neurales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pilar Cidad Velasco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/04\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Pedro Bola\u00f1os Hernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: nieves (secretario) P\u00e9rez gonz\u00e1lez <\/li>\n<li> Leza cerro Juan  Carlos (vocal)<\/li>\n<li>ar\u00e1nzazu Tabernero urbieta (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pilar Cidad Velasco El tratamiento de los astrocitos con lipopolisac\u00e1rido (lps) promueve la expresi\u00f3n transcripcional del transportador [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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