{"id":29911,"date":"2018-03-09T09:23:15","date_gmt":"2018-03-09T09:23:15","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismo-de-accion-y-activacion-de-la-quinasa-inducida-por-interferon-pkr\/"},"modified":"2018-03-09T09:23:15","modified_gmt":"2018-03-09T09:23:15","slug":"mecanismo-de-accion-y-activacion-de-la-quinasa-inducida-por-interferon-pkr","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismo-de-accion-y-activacion-de-la-quinasa-inducida-por-interferon-pkr\/","title":{"rendered":"Mecanismo de acci\u00f3n y activaci\u00f3n de la quinasa inducida por interferon, pkr"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Angel Garc\u00eda <\/strong><\/h2>\n<p>Los interferones son citoquinas que producen las c\u00e9lulas principalmente en respuesta a la infecci\u00f3n viral.  tienen funciones antivirales, inmunomoduladoras y antiproliferativas induciendo la regulaci\u00f3n de m\u00e1s de 100 genes. La prote\u00edna mejor caracterizada inducida por interferones es la prote\u00edna quinasa dependiente de arn bicatenario, pkr. Esta enzima tiene varias funciones biol\u00f3gicas: media en gran medida la antiviral del interfer\u00f3n, controla el crecimiento y la diferenciaci\u00f3n celular, es una prote\u00edna de respuesta a estr\u00e9s, puede funcionar como supresora de tumores y participa en varias rutas de se\u00f1alizaci\u00f3n celular.  estas funciones son producidas a trav\u00e9s de la inhibici\u00f3n de la s\u00edntesis de prote\u00edna que pkr causa al fosforilar al factor de iniciaci\u00f3n de la traducci\u00f3n eif2a y a trav\u00e9s de la activaci\u00f3n del factor de transcripci\u00f3n nfkb que regula la respuesta inflamatoria celular. Adem\u00e1s, a trav\u00e9s de estos dos mecanismos, pkb puede inducir muerte celular programada o apoptosis.  el control de la traducci\u00f3n que ejerce pkr est\u00e1 bien definido, sin embargo aun no est\u00e1 bien caracterizado el proceso de activaci\u00f3n del factor de transcripci\u00f3n nfkb, ni el proceso por el cual pkr provoca apoptosis. As\u00ed, los objetivos principales de esta tesis fueron:  * la identificaci\u00f3n de mol\u00e9culas intermediarias en la ruta de activaci\u00f3n de nfkb por pkr.  * la caracterizaci\u00f3n de las rutas de activaci\u00f3n de caspasas que provocan la apoptosis inducida por pkr.  * el estudio del comportamiento de las c\u00e9lulas que tienen inhibida la ruta de se\u00f1alizaci\u00f3n del arn bicatenario a trav\u00e9s de la expresi\u00f3n de la prote\u00edna inhibidora de pkr del virus vaccinia, e3l.  usando t\u00e9cnicas bioqu\u00edmicas, gen\u00e9ticas e inmunol\u00f3gicas, identificamos a las prote\u00ednas de la familia traf como prote\u00ednas moduladoras que pueden interaccionar con el dominio quinasa de pkr y que a su vez, est\u00e1n participando en la activaci\u00f3n del factor de transcripci<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismo de acci\u00f3n y activaci\u00f3n de la quinasa inducida por interferon, pkr<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismo de acci\u00f3n y activaci\u00f3n de la quinasa inducida por interferon, pkr <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Angel Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/04\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda no Esteban Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Ortin monton <\/li>\n<li>carmen Rivas vazquez (vocal)<\/li>\n<li>Jos\u00e9 Alcami pertejo (vocal)<\/li>\n<li>Rafael Mu\u00f1oz fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Angel Garc\u00eda Los interferones son citoquinas que producen las c\u00e9lulas principalmente en respuesta a la infecci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[21581,22623,14725,84336,23995,15185],"class_list":["post-29911","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-carmen-rivas-vazquez","tag-jose-alcami-pertejo","tag-juan-ortin-monton","tag-maria-angel-garcia","tag-maria-no-esteban-rodriguez","tag-rafael-munoz-fernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29911","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=29911"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29911\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=29911"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=29911"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=29911"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}