{"id":29920,"date":"2018-03-09T09:23:16","date_gmt":"2018-03-09T09:23:16","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cardiotrofina-1-implicaciones-en-la-proteccion-frente-al-dano-y-la-regeneracion-hepatica\/"},"modified":"2018-03-09T09:23:16","modified_gmt":"2018-03-09T09:23:16","slug":"cardiotrofina-1-implicaciones-en-la-proteccion-frente-al-dano-y-la-regeneracion-hepatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/cardiotrofina-1-implicaciones-en-la-proteccion-frente-al-dano-y-la-regeneracion-hepatica\/","title":{"rendered":"Cardiotrofina-1: implicaciones en la protecci\u00f3n frente al da\u00f1o y la regeneraci\u00f3n hep\u00e1tica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Naiara Beraza Aguilar <\/strong><\/h2>\n<p>La cardiotrofina-1 (ct-1) pertenece a la familia de la interleuquina-6 y fue descrita inicialmente como una citoquina secretada por cardiomiocitos con funciones protectoras en c\u00e9lulas card\u00edacas y neuronales. Este trabajo identifica a ct-1 como una citoquina con una funci\u00f3n claramente antiapopt\u00f3tica en hepatocitos. Cinco l\u00edneas de evidencia lo demuestran:  a,- ct-1 e secretada por los hepatocitos en cultivo en condiciones de privaci\u00f3n de suero y ante est\u00edmulos proapopt\u00f3ticos como el tgf-beta.  b,- ct-1 reduce la muerte provocada por tgf-beta en hepatocitos primarios.  c,- la presencia de anticuerpos anti ct-1 reduce la viabilidad de los hepatocitos en cultivo.  d,- ct-1 activa las v\u00edas de se\u00f1alizaci\u00f3n antiapopt\u00f3ticas stat-3, erk 1\/2 y akt e induce la traslocaci\u00f3n al n\u00facleo de nf-kb y finalmente.  e,- la administraci\u00f3n de un adenovirus que codifica para el gen de ct-1 (adct-1) previa a un da\u00f1o hep\u00e1tico agudo mejora la supervivenc ia, la homeostasis del h\u00edgado y reduce la apoptosis en modelos experimentales de fallo hep\u00e1tico fulminante en rata y rat\u00f3n.  durante el proceso de regeneraci\u00f3n hep\u00e1tica se product un aumento en la expresi\u00f3n de mol\u00e9culas antiapopt\u00f3ticas como son las prostaglandinas (pgs) y el factor de crecimiento de endotelio vascular (vegf). En este trabajo demostramos que la expresi\u00f3n de ct-1 se induce durante la regeneraci\u00f3n hep\u00e1tico coincidiendo con la proliferaci\u00f3n de hepatocitos y que la responsable de la s\u00edntesis de pgs durante este periodo es la isoforma inducible de la enzima ciclooxigenasa (cox);cox-2. La inhibici\u00f3n de esta enzima durante la proliferaci\u00f3n hepatocitaria provoca la disminuci\u00f3n de los niveles de ct-1, la p\u00e9rdida de la isoforma vegf188 as\u00ed como el bloqueo de la proliferaci\u00f3n hepatocitaria y la inducci\u00f3n de la apoptosis. La administraci\u00f3n del adct-1 antes de la inhibici\u00f3n de cox-2  revierte el bloqueo de la regeneraci\u00f3n hep\u00e1tica reestableciendo los niveles de pgs<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cardiotrofina-1: implicaciones en la protecci\u00f3n frente al da\u00f1o y la regeneraci\u00f3n hep\u00e1tica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cardiotrofina-1: implicaciones en la protecci\u00f3n frente al da\u00f1o y la regeneraci\u00f3n hep\u00e1tica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Naiara Beraza Aguilar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/04\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Matilde Bustos De Abajo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Prieto vltue\u00f1a <\/li>\n<li>joan Claria enrich (vocal)<\/li>\n<li>raul Jes\u00fas Andrade bellido (vocal)<\/li>\n<li>jordi Muntan\u00e9 relat (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Naiara Beraza Aguilar La cardiotrofina-1 (ct-1) pertenece a la familia de la interleuquina-6 y fue descrita inicialmente [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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