{"id":29929,"date":"2004-03-05T00:00:00","date_gmt":"2004-03-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/una-nueva-estrategia-de-qua%c2%admica-combinatoria-para-el-diseno-y-modificacion-de-dominios-proteicos\/"},"modified":"2004-03-05T00:00:00","modified_gmt":"2004-03-05T00:00:00","slug":"una-nueva-estrategia-de-qua%c2%admica-combinatoria-para-el-diseno-y-modificacion-de-dominios-proteicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-organica\/una-nueva-estrategia-de-qua%c2%admica-combinatoria-para-el-diseno-y-modificacion-de-dominios-proteicos\/","title":{"rendered":"Una nueva estrategia de qu\u00edmica combinatoria para el dise\u00f1o y modificaci\u00f3n de dominios proteicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Javier Pastor Porras <\/strong><\/h2>\n<p>En la presente tesis doctoral se ha desarrollado una nueva estrategia de qu\u00edmica combinatoria para la modificaci\u00f3n de la h\u00e9lice alfa c-terminal del dominio b de la prote\u00edna a de staphylococcus aureus, extensible a la  modificaci\u00f3n de otras prote\u00ednas naturales. La metodolog\u00e1i se basa en la s\u00edntesis de quimiotecas \u00abone-bead-one-compound\u00bb de an\u00e1logos de este p\u00e9ptido y su evaluaci\u00f3n medainte un ensayo de fluorescencia, el cual es capaz de revelar las unidades de resina que contienen un compuesto activo al volverlas fluorescentes. La identidad de los p\u00e9ptidos contenidos en estas unidades de resina se revela por secuenciaci\u00f3n por maldi-tof psd.  la metodolog\u00eda desarrollada ha sido probada con \u00e9xito sobre una quimioteca de 300 candidatos generada por permutaci\u00f3n de cuatro de los amino\u00e1cidos de la h\u00e9lice c-terminal del dominio b. El trabajo con esta quimioteca ha permitido identificar dos p\u00e9ptidos capaces de sustituir esta h\u00e9lice natural para dar lugar a la formacion de nuevos \u00abdominios b\u00bb m\u00e1s estables y activos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Una nueva estrategia de qu\u00edmica combinatoria para el dise\u00f1o y modificaci\u00f3n de dominios proteicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Una nueva estrategia de qu\u00edmica combinatoria para el dise\u00f1o y modificaci\u00f3n de dominios proteicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Javier Pastor Porras <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ernest Giralt Lledo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Albericio palomera <\/li>\n<li>mauricio Garcia mateu (vocal)<\/li>\n<li>angel Messeguer peypoch (vocal)<\/li>\n<li>cristina Carre\u00f1o serraima (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Javier Pastor Porras En la presente tesis doctoral se ha desarrollado una nueva estrategia de qu\u00edmica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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