{"id":30012,"date":"2004-07-05T00:00:00","date_gmt":"2004-07-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-endoglina-en-los-mecanismos-de-senalizacion-celular-de-tgf-beta1-implicados-en-la-acumulacion-de-matriz-extracelular\/"},"modified":"2004-07-05T00:00:00","modified_gmt":"2004-07-05T00:00:00","slug":"papel-de-la-endoglina-en-los-mecanismos-de-senalizacion-celular-de-tgf-beta1-implicados-en-la-acumulacion-de-matriz-extracelular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/papel-de-la-endoglina-en-los-mecanismos-de-senalizacion-celular-de-tgf-beta1-implicados-en-la-acumulacion-de-matriz-extracelular\/","title":{"rendered":"Papel de la endoglina en los mecanismos de se\u00f1alizaci\u00f3n celular de tgf-beta1 implicados en la acumulaci\u00f3n de matriz extracelular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan a Obreo Pintos <\/strong><\/h2>\n<p>La acumulaci\u00f3n de matriz extracelular (mec) que se observa en la insuficiencia renal cr\u00f3nica, puede ser debida en parte al efecto del factor de crecimiento transformante-betal (tgf-beta1) sobre las c\u00e9lulas mesangiales (cm). En el ri\u00f1\u00f3n, el papel cr\u00edtico del tgf-betal se ha reconocido en diversas patolog\u00edas renales caracterizadas por la acumulaci\u00f3n progresiva de mec que conduce al desarrollo de glomeruloesclerosis. Las acciones  biol\u00f3gicas del tgf-beta1 est\u00e1n mediadas por dos receptores de membrana espec\u00edficos (serina-treonina quinasas). Adem\u00e1s se han identificado dos prote\u00ednas asociadas a los receptores de tgf-beta, betaglicano y endoglina. Se ha descrito que endoglina est\u00e1 sobreexpresada en determinadas patolog\u00edas fibr\u00f3ticas y que adem\u00e1s, inhibe parcialmente las respuestas a tgf-beta estudiadas. Nosotros proporcionamos la primera evidencia de la presencia de endoglina en cm, as\u00ed como el aumento de su expresi\u00f3n inducido por tgf-beta1. Nuestro estudios sobre endoglina continuaron en mioblastos l6e9, que no expresan endoglina end\u00f3gena y mioblastos que hab\u00edan sido transfectados con el gen de la endoglina humana. Demostramos que la expresi\u00f3n de endoglina en mioblastos reduce la acumulaci\u00f3n de col\u00e1geno y fibronectina basal y el efecto de tgf-beta1 sobre la acumulaci\u00f3n de colageno. adem\u00e1s, endoglina reduce en un 80% la expresi\u00f3n del factor de crecimiento del tejido conectivo (ctgf), un mediador de los efectos pro-fibr\u00f3ticos de tgf-beta. Tambi\u00e9n estudiamos si las v\u00edas de las mapk estaban implicadas en los efectos de tgf-beta1 sobre la acumulaci\u00f3n de col\u00e1geno y la expresi\u00f3n de ctgf, y la posible modulaci\u00f3n de estas v\u00edas por parte de endoglina. en primer lugar nuestros resultados demostraron que tgf-beta1 activa las v\u00edas de p38 y erk1\/2, pero no jnk. La ruta de p38 es directa y necesaria para el efecto de tgf-beta1 sobre col\u00e1geno independientemente de la expresi\u00f3n de endoglina. Los estudios de la ruta de erk1\/2 i<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la endoglina en los mecanismos de se\u00f1alizaci\u00f3n celular de tgf-beta1 implicados en la acumulaci\u00f3n de matriz extracelular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la endoglina en los mecanismos de se\u00f1alizaci\u00f3n celular de tgf-beta1 implicados en la acumulaci\u00f3n de matriz extracelular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan a Obreo Pintos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alicia Rodr\u00edguez Barbero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  monica De la fuente del rey <\/li>\n<li>atanasio Pandiella alonso (vocal)<\/li>\n<li>Marta Saura redondo (vocal)<\/li>\n<li> Botella cubells Luisa Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan a Obreo Pintos La acumulaci\u00f3n de matriz extracelular (mec) que se observa en la insuficiencia renal [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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