{"id":30055,"date":"2004-10-05T00:00:00","date_gmt":"2004-10-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-inmunofenota%c2%adpico-de-contenido-de-adn-y-factores-pronosticos-en-pacientes-con-mieloma-multiple-mm-tratados-con-quimioterapia-convencional\/"},"modified":"2004-10-05T00:00:00","modified_gmt":"2004-10-05T00:00:00","slug":"analisis-inmunofenota%c2%adpico-de-contenido-de-adn-y-factores-pronosticos-en-pacientes-con-mieloma-multiple-mm-tratados-con-quimioterapia-convencional","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/analisis-inmunofenota%c2%adpico-de-contenido-de-adn-y-factores-pronosticos-en-pacientes-con-mieloma-multiple-mm-tratados-con-quimioterapia-convencional\/","title":{"rendered":"An\u00e1lisis inmunofenot\u00edpico, de contenido de adn y factores pron\u00f3sticos en pacientes con mieloma m\u00faltiple (mm) tratados con quimioterapia convencional"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gonzalez Fraile M. Isabel <\/strong><\/h2>\n<p>En el presente trabajo doctoral nos hemos propuesto un triple objetivo general: primero, analizar las caracter\u00edsticas inmunofenot\u00edpicas de las c\u00e9lulas mielomatosas en una serie amplia de pacientes con mm; segundo, determinar asociaciones en expresi\u00f3n antig\u00e9nica y las alteraciones las gen\u00e9ticas presentes en la c\u00e9lula mielomatosa; y por \u00faltimo, realizar un an\u00e1lisis de factores pron\u00f3sticos. As\u00ed, se demuestra que la  cp mielomatosa presenta un fenotipo heterog\u00e9neo que se traduce en una diversidad de perfiles fenot\u00edpicos. Adem\u00e1s se constata una asociaci\u00f3n entre contenido de adn y fenotipo de la cp mielomatosa: la presencia de hiperdiploid\u00eda de reactividad para cd20, cd28 y cd45; por otro lado, la existencia de biclonalidad de adn se asocia con expresi\u00f3n de cd28 y cd45. En la misma l\u00ednea, se demuestra asociaci\u00f3n entre ganancias de cromosomas concretos (cromosomas 6,9 y 17) y expresi\u00f3n de cd56 en ausencia de cd20. El inmunofenotipo no parece tener un papel determinante en el pron\u00f3stico del mm. La combinaci\u00f3n de siete factores que aportan informaci\u00f3n sobre las caracter\u00edsticas de la c\u00e9lula neopl\u00e1stica (fase s), la masa tumoral (infiltraci\u00f3n por cp en mo, ldh, b2microglobulina y alb\u00famina s\u00e9ricas), y la situaci\u00f3n del hu\u00e9sped (edad y estado general) permite confeccionar un \u00edndice pron\u00f3stico que estratifica a los pacientes con mm en cuatro grupos de riesgo. De los pacientes que mueren dentro del primer a\u00f1o tras el diagn\u00f3stico la gran mayor\u00eda presenta tres o m\u00e1s de las siguientes caracter\u00edsticas: niveles incrementados de b2microglobulina y ldh s\u00e9ricas, porcentaje elevado de cp en fase s, aumento del grado de infiltraci\u00f3n medular por cp determinado por cmf, edad mayor 65 a\u00f1os e hipoalbuminemia marcada.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis inmunofenot\u00edpico, de contenido de adn y factores pron\u00f3sticos en pacientes con mieloma m\u00faltiple (mm) tratados con quimioterapia convencional<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis inmunofenot\u00edpico, de contenido de adn y factores pron\u00f3sticos en pacientes con mieloma m\u00faltiple (mm) tratados con quimioterapia convencional <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gonzalez Fraile M. Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Fernando San Miguel Izquierdo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: agustin Rios gonzalez <\/li>\n<li>Fernando Ramos ortega (vocal)<\/li>\n<li>Mar\u00eda  consuelo Juan a Del ca\u00f1izo fernandez roldan (vocal)<\/li>\n<li>salvador Mart\u00edn algarra (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonzalez Fraile M. Isabel En el presente trabajo doctoral nos hemos propuesto un triple objetivo general: primero, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9386],"tags":[9428,61336,84677,9596,9401,61589],"class_list":["post-30055","post","type-post","status-publish","format-standard","hentry","category-salamanca","tag-agustin-rios-gonzalez","tag-fernando-ramos-ortega","tag-gonzalez-fraile-m-isabel","tag-jesus-fernando-san-miguel-izquierdo","tag-maria-consuelo-juan-a-del-canizo-fernandez-roldan","tag-salvador-martin-algarra"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30055","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=30055"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30055\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=30055"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=30055"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=30055"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}