{"id":30115,"date":"2018-03-09T09:23:35","date_gmt":"2018-03-09T09:23:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-la-protea%c2%adna-oligomerica-de-la-matriz-de-carta%c2%adlago-expresion-del-dominio-c-terminal\/"},"modified":"2018-03-09T09:23:35","modified_gmt":"2018-03-09T09:23:35","slug":"caracterizacion-de-la-protea%c2%adna-oligomerica-de-la-matriz-de-carta%c2%adlago-expresion-del-dominio-c-terminal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-la-protea%c2%adna-oligomerica-de-la-matriz-de-carta%c2%adlago-expresion-del-dominio-c-terminal\/","title":{"rendered":"Caracterizaci\u00f3n de la prote\u00edna oligom\u00e9rica de la matriz de cart\u00edlago. expresi\u00f3n del dominio c-terminal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Belen Blazquez Gonz\u00e1lez <\/strong><\/h2>\n<p>La prote\u00edna oligom\u00e9rica de la matriz del cart\u00edlago (comp), conocida tambi\u00e9n como trombospondina 5, es una glicoprote\u00edna con una elevada masa molecular (520 kda). Es una prote\u00edna altamente ani\u00f3nica debido a su elevado contenido en asp\/asn y glu\/gln, que constituyen m\u00e1s del 30% del total de sus residuos. se trata de un homopent\u00e1mero constituido por cinco subunidades id\u00e9nticas, cada una de ellas con una masa molecular de aproximadamente 120 kda. Cada una de estas subunidades consta de:  * un dominio globular carboxilo terminal.  * siete dominios de uni\u00f3n a calcio o repeticiones tipo 3.  * cuatro dominio de tipo egf o repeticiones tipo 2.  * la regi\u00f3n n-terminal.  inicialmente se aisl\u00f3  y purific\u00f3 la comp a partir de cart\u00edlago aticular humano. A partir de esta prote\u00edna purificada se obtuvieron anticuerpos policlonales anti-comp humana en conejos. Se produjeron tambi\u00e9n anticuerpos monoclonales anti-comp humana en rat\u00f3n, y estos anticuerpos fueron de gran utilidad parala detecci\u00f3n de comp humana en fluidos biol\u00f3gicos (l\u00edquido sinovial y suero) de pacientes con osteoartritis en rodilla.  no est\u00e1 determinada completamente la funcionalidad biol\u00f3gica de la comp, pero al dominio que se le ha atribuido alguna funci\u00f3n ha sido al dominio globular carboxilo terminal. Por tanto decidimos expresar el fragmento c-terminal en tres sistemas de expresi\u00f3n tales como: e.Coli, pichia pastoris y baculovirus. De los tres sistemas de expresi\u00f3n, s\u00f3lo p.Pastoris nos permiti\u00f3 obtener el dominio c-terminal completamente puro.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de la prote\u00edna oligom\u00e9rica de la matriz de cart\u00edlago. expresi\u00f3n del dominio c-terminal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de la prote\u00edna oligom\u00e9rica de la matriz de cart\u00edlago. expresi\u00f3n del dominio c-terminal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Belen Blazquez Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Vivanco Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 gregorio Gavilanes franco <\/li>\n<li>eduardo Espeso fern\u00e1ndez (vocal)<\/li>\n<li> Rios benitez vivian maite de los (vocal)<\/li>\n<li>Carlos Pastor vargas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Belen Blazquez Gonz\u00e1lez La prote\u00edna oligom\u00e9rica de la matriz del cart\u00edlago (comp), conocida tambi\u00e9n como trombospondina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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