{"id":30118,"date":"2018-03-09T09:23:36","date_gmt":"2018-03-09T09:23:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-y-sa%c2%adntesis-de-inhbidores-del-enzima-lactato-deshidrogenasa-de-plasmodium-falciparum\/"},"modified":"2018-03-09T09:23:36","modified_gmt":"2018-03-09T09:23:36","slug":"diseno-y-sa%c2%adntesis-de-inhbidores-del-enzima-lactato-deshidrogenasa-de-plasmodium-falciparum","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-y-sa%c2%adntesis-de-inhbidores-del-enzima-lactato-deshidrogenasa-de-plasmodium-falciparum\/","title":{"rendered":"Dise\u00f1o y s\u00edntesis de inhbidores del enzima lactato deshidrogenasa de plasmodium falciparum"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raquel Gabarro Carrion <\/strong><\/h2>\n<p>La malaria es actualmente una de las causas de mayor morbilidad y mortalidad en el mundo. Se estima que existen entre 400-500 millones de casos cl\u00ednicos por a\u00f1o y que entre 1,5 &#8211; 2,7 millones de personas mueren a causa de dicha enfermedad. Aunque la enfermedad ha sido erradicada en la mayor parte de las zonas templadas y desarrolladas de la tierra, todav\u00eda contin\u00faa siendo end\u00e9mica en la mayoria de las zonas tropicales y subtropicales. El cuarenta por ciento de la poblaci\u00f3n mundial vive en zonas end\u00e9micas.  la malaria es causada por protozoos pertenecientes al g\u00e9nero plasmodium, de entre todas las especies de plamodium, cuatro infectan al hombre: plamodium falciparum, plasmodium vivax, plasmodium ovale y plasmodium malare, siendo la especie falciparum, la sometida a estudio en este trabajo.  los tratamientos actuales de la enfermedad incluyen f\u00e1rmacos como la cloroquina, quinina, quinidina, halofantrina, sulfonamidas, etc. Lejos de ser totalmente eficaces, actualmente se hace necesario el uso de combinaciones de los anteriores para combatir la enfermedad, teniendo como consecuencia la alta frecuencia de aparici\u00f3n de resistencias a dichos medicamentos.  existe una necesidad urgente de nuevos compuestos con actividad antimal\u00e1rica, con nuevos mecanismos de acci\u00f3n y que permitan un tratamiento eficaz y m\u00e1s seguro de la enfermedad. Dentro de los nuevos mecanismos de acci\u00f3n propuestos, el enzima lactato deshidrogenasa (ldh) de plasmodium falciparum es una de las dianas antimal\u00e1ricas m\u00e1s aceptadas por su grado de validaci\u00f3n y su conocimiento estructural. Dicho enzima est\u00e1 involucrado en la forma de obtenci\u00f3n de energ\u00eda por parte del par\u00e1sito, por lo que la inhibici\u00f3n catal\u00edtica de e\u00e9sta, presumiblemente, llevar\u00eda a la muerte del par\u00e1sito. a tal objeto, se ha llevado a cabo el dise\u00f1o, s\u00edntesis y evaluaci\u00f3n biol\u00f3gica de compuestos que presentan inhibici\u00f3n de dicho enzima.  a trav\u00e9s de c\u00e1lculos te\u00f3ricos, usando co<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o y s\u00edntesis de inhbidores del enzima lactato deshidrogenasa de plasmodium falciparum<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o y s\u00edntesis de inhbidores del enzima lactato deshidrogenasa de plasmodium falciparum <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raquel Gabarro Carrion <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Lavandera Diaz Jos\u00e9 Luis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda del carmen Avenda\u00f1o l\u00f3pez <\/li>\n<li>rosa Mar\u00eda Claramunt vallesp\u00ed (vocal)<\/li>\n<li>Jos\u00e9 Elguero bertolini (vocal)<\/li>\n<li> G\u00f3mez de las heras federico (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raquel Gabarro Carrion La malaria es actualmente una de las causas de mayor morbilidad y mortalidad en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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