{"id":30149,"date":"2018-03-09T09:23:38","date_gmt":"2018-03-09T09:23:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/contribucion-de-la-generalidad-de-radicales-libres-de-oxigeno-en-la-pancreatitis-aguda-inducida-por-obstruccion-bilio-pancreatica-estudio-del-efecto-de-la-n-acetilcisteina\/"},"modified":"2018-03-09T09:23:38","modified_gmt":"2018-03-09T09:23:38","slug":"contribucion-de-la-generalidad-de-radicales-libres-de-oxigeno-en-la-pancreatitis-aguda-inducida-por-obstruccion-bilio-pancreatica-estudio-del-efecto-de-la-n-acetilcisteina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/contribucion-de-la-generalidad-de-radicales-libres-de-oxigeno-en-la-pancreatitis-aguda-inducida-por-obstruccion-bilio-pancreatica-estudio-del-efecto-de-la-n-acetilcisteina\/","title":{"rendered":"Contribucion de la generalidad de radicales libres de oxigeno en la pancreatitis aguda inducida por obstruccion bilio-pancreatica. estudio del efecto de la n-acetilcisteina."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Sevillano Marcos Sara Mar\u00eda <\/strong><\/h2>\n<p>La pancreatitis aguda (pa) es una enfermedad inflamatoria cuya amplificaci\u00f3n puede provocar complicaciones sist\u00e9micas e incluso la muerte. Afortunadamente, la pa suele ser un proceso autolimitante, y los da\u00f1os morfol\u00f3gicos y funcionales sufridos pueden repararse en un proceso de regeneraci\u00f3n pancre\u00e1tica. Un exceso de radicales libres de ox\u00edgeno (rlo), mecanismo patog\u00e9nico involucrado en la pa, causa da\u00f1o oxidativo sobre diferentes componentes celulares, amplifica la respuesta inflamatoria, y est\u00e1 implicado en la regulaci\u00f3n de la proliferaci\u00f3n en diferentes tipos celulares. Mediante la administraci\u00f3n profil\u00e1ctica intraperitoneal de n-acetilciste\u00edna (nac), precursor de glutati\u00f3n con efecto antioxidante y antiinflamatorio, se previno la generaci\u00f3n temprana de rlo durante la pa inducida por obstrucci\u00f3n bilio-pancre\u00e1tica (obp) en rata. De este modo la nac previno los desajustes de la homeostasis del ca2+ y la cumulaci\u00f3n de enzimas digestivas en las c\u00e9lulas acinares, probablemente impidiendo la oxidaci\u00f3n de membranas celulares y prote\u00ednas como las del citoesqueleto, preservando sus funciones y paliando el bloqueo de la exocitosis inducido por la obp y la gravedad de la enfermedad.  la administraci\u00f3n de nac redujo y retras\u00f3 la respuesta inflamatoria local e inhibi\u00f3 su amplificaci\u00f3n sist\u00e9mica, quiz\u00e1s mediante la supresi\u00f3n del efecto quimioatrayente y activador de leucocitos de los rlo, capaces de promover la producci\u00f3n de citocinas proinflamatorias y mol\u00e9culas de adhesi\u00f3n, favoreciendo la infiltraci\u00f3n tisular y el da\u00f1o asociado. Estos efectos se deben a la activaci\u00f3n del factor de transcripci\u00f3n nuclear nf-kb dependiente de rlo, inhibida por nac en diversos modelos experimentales.  en cuanto a la progresi\u00f3n del ciclo celular, comprobamos que los rlo juegan un papel clave promoviendo la proliferaci\u00f3n de las c\u00e9lulas acinares pancre\u00e1ticas.  la eliminaci\u00f3n de la obp despu\u00e9s de 24 h de pa limit\u00f3 eficazmente<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Contribucion de la generalidad de radicales libres de oxigeno en la pancreatitis aguda inducida por obstruccion bilio-pancreatica. estudio del efecto de la n-acetilcisteina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Contribucion de la generalidad de radicales libres de oxigeno en la pancreatitis aguda inducida por obstruccion bilio-pancreatica. estudio del efecto de la n-acetilcisteina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Sevillano Marcos Sara Mar\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Isabel De Dios Bay\u00f3n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 ram\u00f3n Alonso pe\u00f1a <\/li>\n<li>lLuis CasaJuan a felis (vocal)<\/li>\n<li>Rafael De llorens duran (vocal)<\/li>\n<li>Juan  pedro Bola\u00f1os hernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sevillano Marcos Sara Mar\u00eda La pancreatitis aguda (pa) es una enfermedad inflamatoria cuya amplificaci\u00f3n puede provocar complicaciones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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