{"id":30182,"date":"2018-03-09T09:23:41","date_gmt":"2018-03-09T09:23:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aspectos-del-desarrollo-precla%c2%adnico-y-cla%c2%adnico-de-un-nuevo-anestesico-local-ciprocaa%c2%adna-iqb-9302\/"},"modified":"2018-03-09T09:23:41","modified_gmt":"2018-03-09T09:23:41","slug":"aspectos-del-desarrollo-precla%c2%adnico-y-cla%c2%adnico-de-un-nuevo-anestesico-local-ciprocaa%c2%adna-iqb-9302","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aspectos-del-desarrollo-precla%c2%adnico-y-cla%c2%adnico-de-un-nuevo-anestesico-local-ciprocaa%c2%adna-iqb-9302\/","title":{"rendered":"Aspectos del desarrollo precl\u00ednico y cl\u00ednico de un nuevo anest\u00e9sico local: ciproca\u00edna (iqb-9302)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Angeles Santos Ampuero <\/strong><\/h2>\n<p>En un intento de mejorar la distribuci\u00f3n y la fijaci\u00f3n tisular de los anest\u00e9sicos locales (al), se ha desarrollado una serie de al de tipo amida con un grupo ciclopropilo unido a la cadena lateral. Esta modificaci\u00f3n permite reunir en una misma mol\u00e9cula las propiedades est\u00e9ricas y lipofilicas de los al m\u00e1s potentes, como la bupivaca\u00edna, con una mayor resistencia a la metabolizaci\u00f3n enzim\u00e1tica prolongando as\u00ed su acci\u00f3n anest\u00e9sica. De estos derivados, el m\u00e1s representativo es la ciproca\u00edna (c\u00f3digo de propuesta cl\u00ednica, iqb-9302). sus efectos anest\u00e9sicos han sido estudiados en distintos modelos animales, mostrando un \u00edndice terap\u00e9utico superior al de la lidoca\u00edna y la bupivaca\u00edna. tambi\u00e9n se han realizado dos ensayos cl\u00ednicos en fase i para evaluar los efectos anest\u00e9sicos locales y la tolerabilidad de la administraci\u00f3n intrad\u00e9rmica del a ciproca\u00edna en comparaci\u00f3n con placebo y bupivaca\u00edna.  esta tesis doctoral se enmarca en el programa de desarrollo precl\u00ednico y cl\u00ednico de la ciproca\u00edna. Por un lado, se han caracterizado los efectos hemodin\u00e1micos de este al administrado por v\u00eda intravenosa a ratas anestesiadas. este es el primero de una serie de trabajos cuyo objetivo global es la caracterizaci\u00f3n de la acci\u00f3n farmacol\u00f3gica a nivel cardiovascular de la ciproca\u00edna. Por otra parte, se ha completado un ensayo cl\u00ednico en fase i en voluntarios sanos para comparar la eficacia y la tolerabilidad de soluciones al 0,25 y 0,50% de ciproca\u00edna y bupivaca\u00edna en el bloqueo del nervio cubital a nivel de la mu\u00f1eca. Este es el tercero de una serie de 22 ensayos cl\u00ednicos en fase i, ii y iii que configuran el programa de desarrollo cl\u00ednico de este nuevo al. En el primer estudio, la ciproca\u00edna mostr\u00f3 unos efectos hemodin\u00e1micos similares a los de la bupivaca\u00edna, causando una reducci\u00f3n de la frecuencia cardiaca (fc) y un aumento de la presi\u00f3n arterial media (pam).  este efecto fue dependiente de la dosis, siendo m<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aspectos del desarrollo precl\u00ednico y cl\u00ednico de un nuevo anest\u00e9sico local: ciproca\u00edna (iqb-9302)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aspectos del desarrollo precl\u00ednico y cl\u00ednico de un nuevo anest\u00e9sico local: ciproca\u00edna (iqb-9302) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Angeles Santos Ampuero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Gilsanz Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Rodr\u00edguez montes <\/li>\n<li>Manuel Figueroa jose (vocal)<\/li>\n<li>Francisco L\u00f3pez timogreda (vocal)<\/li>\n<li>joan xavier Comella carnice (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Angeles Santos Ampuero En un intento de mejorar la distribuci\u00f3n y la fijaci\u00f3n tisular de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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