{"id":30204,"date":"2018-03-09T09:23:43","date_gmt":"2018-03-09T09:23:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-exposicion-a-hidrocarburos-aromaticos-sobre-la-regulacion-neuroqua%c2%admica-del-apetito-en-la-rata\/"},"modified":"2018-03-09T09:23:43","modified_gmt":"2018-03-09T09:23:43","slug":"efectos-de-la-exposicion-a-hidrocarburos-aromaticos-sobre-la-regulacion-neuroqua%c2%admica-del-apetito-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/efectos-de-la-exposicion-a-hidrocarburos-aromaticos-sobre-la-regulacion-neuroqua%c2%admica-del-apetito-en-la-rata\/","title":{"rendered":"Efectos de la exposici\u00f3n a hidrocarburos arom\u00e1ticos sobre la regulaci\u00f3n neuroqu\u00edmica del apetito en la rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mor\u00f3n Alc\u00e1zar Lena Beatriz <\/strong><\/h2>\n<p>El neurop\u00e9ptido y, la galanina y los p\u00e9ptidos opiodes presentan una amplia distribuci\u00f3n cerebral, principalmente en el hipot\u00e1lamo, y ejercen un potente efecto orexig\u00e9nico. Por otra parte, cabe rese\u00f1ar que tanto la exposici\u00f3n laboral a hidrocarburos arom\u00e1ticos (tolueno o benceno o xileno) como su abuso deliberado suponen un alto riesgo para la salud originando depresi\u00f3n en el snc entre otros y su mecanismo anorex\u00edgeno es desconocido en el caso del tolueno y benceno.  la metodolog\u00eda empleada consisti\u00f3 en la realizaci\u00f3n de exposiciones agudas y cr\u00f3nicas de la rata a los disolventes, seguidas de un extenso estudio inmunocitoqu\u00edmico regional de la expresi\u00f3n de npy, galanina y reeeptor opioide mu del cual se obtuvieron tinciones sobre cortes cerebrales que fueron analizados posteriormente mediante microscopia \u00f3ptica, empleando un sistema computarizado de an\u00e1lisis de imagen. Adem\u00e1s de un seguimiento diario del peso corporal y la ingesta de alimento, mediante el empleo de jaulas metab\u00f3licas y finalmente un an\u00e1lisis de componentes s\u00e9ricos y hep\u00e1ticos por m\u00e9todos espectrofotom\u00e9tricos.  los resultados obtenidos en este trabajo sugieren la posible implicaci\u00f3n del neurop\u00e9ptido y, la galanina y el sistema opioide a nivel hipotal\u00e1mico en el mecanismo anorex\u00edgeno de tolueno y benceno. Igualmente, demuestran el efecto anorex\u00edgeno de la exposici\u00f3n aguda a diversos hidrocarburos arom\u00e1ticos (tolueno y benceno) en la rata. Sin embargo, estos cambios desaparecen tras la exposici\u00f3n cr\u00f3nica, lo que indica una adaptaci\u00f3n de los mecanismos neuroqu\u00edmicos hipotal\u00e1micos reguladores del apetito. En el caso del xileno, los resultados obtenidos demuestran claramente una ausencia de efecto anorex\u00edgeno tras la exposici\u00f3n aguda o cr\u00f3nica a este disolvente y sugieren una escasa o nula implicaci\u00f3n de los p\u00e9ptidos estudiados en su mecanismo neurot\u00f3xico. por otra parte, se confirma una mayor hepatot\u00f3xicidad con respecto a tolueno y<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la exposici\u00f3n a hidrocarburos arom\u00e1ticos sobre la regulaci\u00f3n neuroqu\u00edmica del apetito en la rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la exposici\u00f3n a hidrocarburos arom\u00e1ticos sobre la regulaci\u00f3n neuroqu\u00edmica del apetito en la rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mor\u00f3n Alc\u00e1zar Lena Beatriz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enrique Echevarr\u00eda Orella<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: lu\u00eds Casis s\u00e1enz <\/li>\n<li> Escanero marc\u00e9n Jes\u00fas Fernando (vocal)<\/li>\n<li>jon Irazusta astiazaran (vocal)<\/li>\n<li>octavio Alda torrubia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mor\u00f3n Alc\u00e1zar Lena Beatriz El neurop\u00e9ptido y, la galanina y los p\u00e9ptidos opiodes presentan una amplia distribuci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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