{"id":30219,"date":"2018-03-09T09:23:44","date_gmt":"2018-03-09T09:23:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/patogenia-de-la-peste-porcina-clasica-papel-de-los-macrofagos-pulmonares-y-celulas-de-kupffer\/"},"modified":"2018-03-09T09:23:44","modified_gmt":"2018-03-09T09:23:44","slug":"patogenia-de-la-peste-porcina-clasica-papel-de-los-macrofagos-pulmonares-y-celulas-de-kupffer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cordoba\/patogenia-de-la-peste-porcina-clasica-papel-de-los-macrofagos-pulmonares-y-celulas-de-kupffer\/","title":{"rendered":"Patogenia de la peste porcina cl\u00e1sica: papel de los macr\u00f3fagos pulmonares y c\u00e9lulas de kupffer"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alejandro Nu\u00f1ez Castel <\/strong><\/h2>\n<p>Para determinar el papel de los macr\u00f3fagos pulmonares y hep\u00e1ticos en la patogenia de la peste porcina cl\u00e1sica (ppc) se inocularon 14 cerdos con la cepa alfort del virus y se sacrificaron por parejas entre los 2 y 17 d\u00edas post inoculaci\u00f3n, utiliz\u00e1ndose dos animales control. Las muestras fueron fijadas en formol y soluci\u00f3n de bouin, para el estudio estructural e inmunohistoqu\u00edmico, desarrollado con la t\u00e9cnica del abc y utilizando anticuerpos frente al ant\u00edgeno v\u00edrico gp55, swc-3, factor viii, il-1a, il-6 y tnf-a, y en glutaraldehido al 2,5% para el estudio ultraestructural.  la detecci\u00f3n del ant\u00edgeno v\u00edrico gp55 se produce desde fechas tempranas de la infecci\u00f3n en el pulm\u00f3n e h\u00edgado, siendo las primeras c\u00e9lulas que aparecen infectadas en ambos \u00f3rganos los macr\u00f3fagos. La replicaci\u00f3n del virus de la ppc, indujo la aparici\u00f3n  de cambios cualitativos y cuantitativos en los macr\u00f3fagos de estos \u00f3rganos, que incluyeron fen\u00f3menos de activaci\u00f3n, un incremento en el n\u00famero de macr\u00f3fagos y de la expresi\u00f3n de citoquinas por los mismos. Estos cambios se produjeron de forma paralela al incremento del n\u00famero de macr\u00f3fagos que sufri\u00f3 la infecci\u00f3n por el virus de la ppc, siendo sin\u00e9rgica la m\u00e1xima expresi\u00f3n de il-1a y tnf-a con la m\u00e1xima detecci\u00f3n del ant\u00edgeno v\u00edrico en ambos \u00f3rganos, y observ\u00e1ndose una diferente cin\u00e9tica de expresi\u00f3n de citoquinas en funci\u00f3n  de la localizaci\u00f3n anat\u00f3mica de las distintas poblaciones macrof\u00e1gicas. La citoquina predominantemente expresada en pulm\u00f3n fue el tnf-a, siendo paralelas la aparici\u00f3n de lesiones en el pulm\u00f3n, a la detecci\u00f3n de ant\u00edgeno v\u00edrico en los tejidos pulmonares y a la expresi\u00f3n sin\u00e9rgica de tnf-a e il1a, fundamentalmente por los mips. en el h\u00edgado, la citoquina mayoritariamente detectada fue la il-1a, expresada principalmente por las c\u00e9lulas de kupffer, mientras que la expresi\u00f3n de il-6 se detect\u00f3 principalmente en los macr\u00f3fagos intersticiales hep\u00e1ti<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Patogenia de la peste porcina cl\u00e1sica: papel de los macr\u00f3fagos pulmonares y c\u00e9lulas de kupffer<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Patogenia de la peste porcina cl\u00e1sica: papel de los macr\u00f3fagos pulmonares y c\u00e9lulas de kupffer <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alejandro Nu\u00f1ez Castel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Librado Carrasco Otero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: amador Jover moyano <\/li>\n<li>l. Vrespeau francois (vocal)<\/li>\n<li>joaqu\u00edn Goyache go\u00f1i (vocal)<\/li>\n<li>Antonio Bernabe salazar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alejandro Nu\u00f1ez Castel Para determinar el papel de los macr\u00f3fagos pulmonares y hep\u00e1ticos en la patogenia de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[973],"tags":[85047,533,1954,36081,85048,62055],"class_list":["post-30219","post","type-post","status-publish","format-standard","hentry","category-cordoba","tag-alejandro-nunez-castel","tag-amador-jover-moyano","tag-antonio-bernabe-salazar","tag-joaquin-goyache-goni","tag-l-vrespeau-francois","tag-librado-carrasco-otero"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30219","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=30219"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30219\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=30219"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=30219"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=30219"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}