{"id":30222,"date":"2018-03-09T09:23:44","date_gmt":"2018-03-09T09:23:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valoracion-del-oncogen-her2-neu-en-cancer-ductal-infiltrante-de-mama-estudio-comparativo-entre-inmunohistoquimica-hibridacion-in-situ-y-analisis-de-imagen\/"},"modified":"2018-03-09T09:23:44","modified_gmt":"2018-03-09T09:23:44","slug":"valoracion-del-oncogen-her2-neu-en-cancer-ductal-infiltrante-de-mama-estudio-comparativo-entre-inmunohistoquimica-hibridacion-in-situ-y-analisis-de-imagen","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valoracion-del-oncogen-her2-neu-en-cancer-ductal-infiltrante-de-mama-estudio-comparativo-entre-inmunohistoquimica-hibridacion-in-situ-y-analisis-de-imagen\/","title":{"rendered":"Valoraci\u00f3n del oncog\u00e9n her2\/neu en cancer ductal infiltrante de mama. estudio comparativo entre inmunohistoquimica, hibridaci\u00f3n in situ y an\u00e1lisis de imagen"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Marquez Lobo Belgica Obdulia <\/strong><\/h2>\n<p>El carcinoma de mama, es una enfermedad heterog\u00e9nea en la que est\u00e1n involucrados m\u00faltiples factores, y en la que se han estudiado gran cantidad de variables clinicopatol\u00f3gicas relacionadas con el pron\u00f3stico. Actualmente han surgido nuevas investigaciones que centran su atenci\u00f3n en el papel que tienen los oncogenes y sus productos en la etiolog\u00eda y el pron\u00f3stico de \u00e9sta entidad as\u00ed como la mejor manera de testificar her2\/neu en las pacientes que recibiran tratamiento antiher; es por esto, que estudiamos la expresi\u00f3n del oncog\u00e9n her2 en una serie de 129 pacientes del hospital cl\u00ednico san cecilio de granada-espa\u00f1a, con carcinoma ductal infiltrante de mama.  el oncog\u00e9n her2, codifica una prote\u00edna transmembrana de 185 kd, con actividad tirosin-quinasa, que tiene homogolog\u00eda parcial con miembros de la familia del receptor del factor de crecimiento epidermal. Se cree que se activa debido a la uni\u00f3n con un ligando (a\u00fan sin identificar), lo que promueve el crecimiento celular. Su sobreexpresi\u00f3n\/amplificaci\u00f3n se ha reportado en aproximadamente un 20-24% de c\u00e1nceres infiltrantes de mama y la sobreexpresi\u00f3n sin amplificaci\u00f3n y viceversa en un 2%.  en nuestra serie, hemos analizado la influencia de her2\/neu sobre la supervivencia global, encontrando que la afecta de una manera significativa, (p mayor 0,001). Utilizamos tres formas de evaluaci\u00f3n de her2\/neu; inmunohistoqu\u00edmica, con dos anticuerpos, uno monoclonal cb11 y el kit herceptest(r)  de dako, hibridaci\u00f3n in situ (cihs) y an\u00e1lisis de imagen y hemos relacionado su sobreexpresi\u00f3n\/amplificaci\u00f3n con algunas variables histopatol\u00f3gicas de valor pron\u00f3stico conocido, encontrando asociaci\u00f3n significativa con afectaci\u00f3n ganglionar, tama\u00f1o, receptores estrog\u00e9nicos, y ki67. De acuerdo a nuestros resultados, es el cb11 el anticuerpo m\u00e1s sensible para detectar her2\/neu especialmente por inmunohistoqu\u00edmica, corroborando la utilidad de \u00e9sta t\u00e9cnica en su evaluaci\u00f3n, si<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valoraci\u00f3n del oncog\u00e9n her2\/neu en cancer ductal infiltrante de mama. estudio comparativo entre inmunohistoquimica, hibridaci\u00f3n in situ y an\u00e1lisis de imagen<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valoraci\u00f3n del oncog\u00e9n her2\/neu en cancer ductal infiltrante de mama. estudio comparativo entre inmunohistoquimica, hibridaci\u00f3n in situ y an\u00e1lisis de imagen <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Marquez Lobo Belgica Obdulia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Aneiros Cachaza Jos\u00e9 Francisco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: guillermo S\u00e1nchez salgado <\/li>\n<li>Javier Esquivias lopez cuervo (vocal)<\/li>\n<li> Torn\u00e9 poyatos pablo Juan (vocal)<\/li>\n<li> L\u00f3pez caballero Jos\u00e9 Javier (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marquez Lobo Belgica Obdulia El carcinoma de mama, es una enfermedad heterog\u00e9nea en la que est\u00e1n involucrados [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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