{"id":30229,"date":"2018-03-09T09:23:45","date_gmt":"2018-03-09T09:23:45","guid":{"rendered":""},"modified":"2018-03-09T09:23:45","modified_gmt":"2018-03-09T09:23:45","slug":"efecto-de-las-lipoprotea%c2%adnas-de-baja-densidad-ldl-sobre-proliferacion-supervivencia-y-va%c2%adas-de-senalizacion-inducidas-por-igf-i-en-celulas-musculares-lisas-vasculares-modulacion-por-oxid","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-las-lipoprotea%c2%adnas-de-baja-densidad-ldl-sobre-proliferacion-supervivencia-y-va%c2%adas-de-senalizacion-inducidas-por-igf-i-en-celulas-musculares-lisas-vasculares-modulacion-por-oxid\/","title":{"rendered":"Efecto de las lipoprote\u00ednas de baja densidad (ldl) sobre proliferaci\u00f3n, supervivencia y v\u00edas de se\u00f1alizaci\u00f3n inducidas por igf-i en c\u00e9lulas musculares lisas vasculares. modulaci\u00f3n por \u00f3xido n\u00edtrico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bel\u00e9n Gonz\u00e1lez Tim\u00f3n <\/strong><\/h2>\n<p>El balance entre proliferaci\u00f3n y supervivencia de c\u00e9lulas musculares lisas vasculares (cmlv) juega un papel cr\u00edtico en el desarrollo de la lesi\u00f3n ateroscler\u00f3tica. Estos procesos est\u00e1n regulados por cambios en la expresi\u00f3n local y en la se\u00f1alizaci\u00f3n del eje igf-i en cmlv de la placa de ateroma. la acumulaci\u00f3n de lipoprote\u00ednas de baja densidad (ldl) y su oxidaci\u00f3n en la pared vascular tienen un papel central en la aterog\u00e9nesis. Recientes evidencias sugieren que la acumulaci\u00f3n de ldl en la pared vascular induce cambios locales en la expresi\u00f3n y se\u00f1alizaci\u00f3n de igf-i. En este trabajo hemos estudiado los efectos de las ldl sobre la proliferaci\u00f3n, supervivencia y v\u00edas de se\u00f1alizaci\u00f3n de igf-i en un modelo de cmvl de neo\u00edntima (cmlv-a10). hemos demostrado que las ldl nativas y oxidadas modulan opuesta y espec\u00edficamente la v\u00eda de se\u00f1alizaci\u00f3n irs-1\/pi3k\/akt inducida por igf-i en cmlv-a10. Este efecto se asocia con una modulaci\u00f3n diferencial de las acciones proliferativas y antiapopt\u00f3tica de igf-i por las ldl en funci\u00f3n de su concentraci\u00f3n y grado de oxidaci\u00f3n.  el \u00f3xido n\u00edtrico (no) modula los efectos finales tanto de igf-i como de ldl en cmlv.  en la \u00faltima parte de este trabajo hemos estudiado su efecto sobre la interacci\u00f3n de ldl e igf-i en nuestro modelo celular. Hemos demostrado que el no es capaz de regular la interacci\u00f3n de igf-i y ldl en se\u00f1alizaci\u00f3n, proliferaci\u00f3n y apoptosis de cmlv-a10.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de las lipoprote\u00ednas de baja densidad (ldl) sobre proliferaci\u00f3n, supervivencia y v\u00edas de se\u00f1alizaci\u00f3n inducidas por igf-i en c\u00e9lulas musculares lisas vasculares. modulaci\u00f3n por \u00f3xido n\u00edtrico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de las lipoprote\u00ednas de baja densidad (ldl) sobre proliferaci\u00f3n, supervivencia y v\u00edas de se\u00f1alizaci\u00f3n inducidas por igf-i en c\u00e9lulas musculares lisas vasculares. modulaci\u00f3n por \u00f3xido n\u00edtrico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bel\u00e9n Gonz\u00e1lez Tim\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Meli\u00e1n P\u00e9rez Elvira M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  monica De la fuente del rey <\/li>\n<li>Manuel Rodr\u00edguez puyol (vocal)<\/li>\n<li>Carlos Zaragoza s\u00e1nchez (vocal)<\/li>\n<li> Asunci\u00f3n ripa Miguel \u00e1ngel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bel\u00e9n Gonz\u00e1lez Tim\u00f3n El balance entre proliferaci\u00f3n y supervivencia de c\u00e9lulas musculares lisas vasculares (cmlv) juega un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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