{"id":30272,"date":"2018-03-09T09:23:49","date_gmt":"2018-03-09T09:23:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-distribucion-y-asociacion-de-cd26-y-cd45r0-en-microdominios-raft-esta-regulada-por-il-12\/"},"modified":"2018-03-09T09:23:49","modified_gmt":"2018-03-09T09:23:49","slug":"la-distribucion-y-asociacion-de-cd26-y-cd45r0-en-microdominios-raft-esta-regulada-por-il-12","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/santiago-de-compostela\/la-distribucion-y-asociacion-de-cd26-y-cd45r0-en-microdominios-raft-esta-regulada-por-il-12\/","title":{"rendered":"La distribuci\u00f3n y asociaci\u00f3n de cd26 y cd45r0 en microdominios raft est\u00e1 regulada por il-12"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan Lojo Rodr\u00edguez <\/strong><\/h2>\n<p>Las prote\u00ednas transmembrana cd26 y cd45 han sido relacionadas con diversos eventos de se\u00f1alizaci\u00f3n mediados por el receptor de c\u00e9lulas t (tcr), lo que entronca de un modo directo con los procesos de activaci\u00f3n y regulaci\u00f3n del sistema inmune. De hecho, la actividad de cd45 es crucial parala funcionalidad de las cascadas de transducci\u00f3n generadas por el tcr tras la presentaci\u00f3n antig\u00e9nica, y cd26 parece actuar como un potente coadyuvante de \u00e9stas. adem\u00e1s, la ausencia o alteraci\u00f3n de las v\u00edas de se\u00f1alizaci\u00f3n a trav\u00e9s de cd45 o cd26 provoca importantes disfunciones en el sistema inmune.  por otro lado, los comportamientos especializados de membrana denominados rafts o membranas resistentes a detergentes (drms) ejercen un papel crucial en la organizaci\u00f3n y acoplamiento de los numerosos componentes implicados en las cascadas de transducci\u00f3n de se\u00f1ales. La interacci\u00f3n entre cd26 y cd45, as\u00ed como su presencia o ausencia en rafts, puede, por lo tanto, ejercer un importante efecto regulador sobre las se\u00f1ales de activaci\u00f3n dependientes de tcr.  en la presente tesis se pretende describir c\u00f3mo il-12, un factor capaz de regular la respuesta celular desencadenada v\u00eda tcr y, en consecuencia, la actividad del sistema inmune, puede realizar su funci\u00f3n a trav\u00e9s de mol\u00e9culas como cd26 y cd45. Dicha citoquina es capaz de favorecer un tipo de respuesta en la que predominan mecanismos celulares y en este estudio se pone de manifiesto su capacidad para generar cambios en la distribuci\u00f3n de cd26 en los distintos compartimentos de membrana. Tambi\u00e9n se ha evaluado el posicionamiento en la superficie celular de mol\u00e9culas de cd45, m\u00e1s concretamente las isoformas de menor peso molecular (cd45r0), que se encuentran interactuando con cd26 en los diferentes dominios de membranas. Se ha demostrado que, de un modo directo o indirecto, cd26 est\u00e1 claramente implicado en la redistribuci\u00f3n de este cd45ro hacia fuera de los microdominios ra<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La distribuci\u00f3n y asociaci\u00f3n de cd26 y cd45r0 en microdominios raft est\u00e1 regulada por il-12<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La distribuci\u00f3n y asociaci\u00f3n de cd26 y cd45r0 en microdominios raft est\u00e1 regulada por il-12 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan Lojo Rodr\u00edguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Montserrat Nogueira \u00e1lvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: germ\u00e1n Sierra marcu\u00f1o <\/li>\n<li>gilles Trav\u00e9 (vocal)<\/li>\n<li>i. Magee anthony (vocal)<\/li>\n<li> L\u00f3pez rodr\u00edguez Jos\u00e9 Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Lojo Rodr\u00edguez Las prote\u00ednas transmembrana cd26 y cd45 han sido relacionadas con diversos eventos de se\u00f1alizaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[977],"tags":[678,58032,85163,85162,85164,2614],"class_list":["post-30272","post","type-post","status-publish","format-standard","hentry","category-santiago-de-compostela","tag-german-sierra-marcuno","tag-gilles-trave","tag-i-magee-anthony","tag-juan-lojo-rodriguez","tag-lopez-rodriguez-jose-luis","tag-montserrat-nogueira-alvarez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30272","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=30272"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30272\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=30272"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=30272"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=30272"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}