{"id":30283,"date":"2018-03-09T09:23:49","date_gmt":"2018-03-09T09:23:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-osteopontina-en-la-esclerosis-multiple-y-su-relacion-con-la-progresion-de-la-enfermedad\/"},"modified":"2018-03-09T09:23:49","modified_gmt":"2018-03-09T09:23:49","slug":"estudio-de-la-osteopontina-en-la-esclerosis-multiple-y-su-relacion-con-la-progresion-de-la-enfermedad","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-osteopontina-en-la-esclerosis-multiple-y-su-relacion-con-la-progresion-de-la-enfermedad\/","title":{"rendered":"Estudio de la osteopontina en la esclerosis m\u00faltiple y su relaci\u00f3n con la progresi\u00f3n de la enfermedad"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Immaculada Pericot Nierga <\/strong><\/h2>\n<p>La esclerosis m\u00faltiple (em) es una enfermedad cr\u00f3nica desmielinizante inflamatoria adquirida del sistema nervioso central de patonenia inmune. La osteopontina (opn) es una citoquina que participa en la inmunidad celular th1 y tiene funciones proinflamatorias: funci\u00f3n quimiot\u00e1ctica, inducci\u00f3n de la proliferaci\u00f3n de c\u00e9lulas b y aumentar la supervivencia celular de c\u00e9lulas inflamatorias; y funciones reparadores: est\u00e1 implicada en la reparaci\u00f3n de tejidos.  se estudiaron 221 pacientes con em y 36 controles sanos (cs). Los pacientes presentaban diferentes formas cl\u00ednicas: 115 em remitente-recurrente (emrr) (46 en remisi\u00f3n, 26 en brotes y 43 en tratamiento con ifn-beta), 35 em secundaria progresiva (emsp) y 71 em primaria progresiva (empp). Los niveles plasm\u00e1ticos de opn fueron cuantificados mediante la t\u00e9cnicas elisa utilizando un kit comercial.  los niveles de opn en plasma son m\u00e1s elevados en pacientes con emsp en comparaci\u00f3n a cs, emrr en remisi\u00f3n y empp, con unas diferencias estad\u00edsticamente significativas. Los niveles plasm\u00e1ticos de opn son significativamente m\u00e1s elevados en pacientes con emrr durante el brote en comparaci\u00f3n a pacientes con emrr en remisi\u00f3n cl\u00ednica (p=0,004), por lo que pensamos que la opn juega un papel en la actividad aguda de la enfermedad. Los niveles de opn son m\u00e1s elevados en pacientes con emsp sin incremento de la discapacidad en el a\u00f1o previo, con unas diferencias estad\u00edsticamente significativas (p=0,005); por lo que creemos que la opn tiene propiedades reparadoras durante la fase progresiva de la emsp. No encontramos diferencias en los niveles plasm\u00e1ticos de opn entre pacientes con empp y cs. Tampoco hallamos diferencias en los niveles de opn en plasma entre aquellos pacientes tratados con ifn-beta de aquellos no tratados.  las conclusiones son:  1,- la opn tiene una funci\u00f3n proinflamatoria en la actividad aguda de la enfermedad.  2,- la opn tiene una actividad reparadora en la fa<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la osteopontina en la esclerosis m\u00faltiple y su relaci\u00f3n con la progresi\u00f3n de la enfermedad<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la osteopontina en la esclerosis m\u00faltiple y su relaci\u00f3n con la progresi\u00f3n de la enfermedad <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Immaculada Pericot Nierga <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Xavier Montalban Gairin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miquel Vilardell tarres <\/li>\n<li>txomin Arbizu urdiain (vocal)<\/li>\n<li>nolasc Acar\u00edn tusell (vocal)<\/li>\n<li>eva Mart\u00ednez c\u00e1ceres (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Immaculada Pericot Nierga La esclerosis m\u00faltiple (em) es una enfermedad cr\u00f3nica desmielinizante inflamatoria adquirida del sistema nervioso [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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