{"id":30285,"date":"2018-03-09T09:23:50","date_gmt":"2018-03-09T09:23:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-sistema-hla-en-la-purpura-trombocitopenica-idiopatica\/"},"modified":"2018-03-09T09:23:50","modified_gmt":"2018-03-09T09:23:50","slug":"estudio-del-sistema-hla-en-la-purpura-trombocitopenica-idiopatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-sistema-hla-en-la-purpura-trombocitopenica-idiopatica\/","title":{"rendered":"Estudio del sistema hla en la p\u00farpura trombocitopenica idiop\u00e1tica"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Paz Arias Raquel De <\/strong><\/h2>\n<p>La p\u00farpura trombocitop\u00e9nica idiop\u00e1tica es un trastorno inmunol\u00f3gico caracterizado por la puesta en marcha de una respuesta inmune espec\u00edfica de tipo celular. destaca por su compleja fisiopatolog\u00eda, donde el factor o factores etiol\u00f3gicos permanecen a\u00fan desconocidos, sin embargo, los factores predisponentes de este proceso son bien conocidos, entre los que destaca el factor gen\u00e9tico, y particularmente el sistema hla. Mediante el empleo de t\u00e9cnicas moleculares de tipoficaci\u00f3n, en este estudio se ha intentado demostrar, la implicaci\u00f3n de \u00e9ste en la patogenia de la p\u00farpura trombocitop\u00e9nica idiop\u00e1tica, su importancia diagn\u00f3stico y pron\u00f3stica, as\u00ed como su papel predictor de la elecci\u00f3n terap\u00e9utica. inicialmente este trabajo consisti\u00f3 en un estudio fenot\u00edpico o por haplotipos y posteriormente genot\u00edpico de la cohorte de pacientes con pti. Posteriormente, este estudio se continu\u00f3, haciendo un an\u00e1lisis comparativo con dos poblaciones control pertenecientes a distinta regi\u00f3n geogr\u00e1fica y grupo \u00e9tnico, un grupo control espa\u00f1ol y un grupo control americano.  y por \u00faltimo se realiz\u00f3 un estudio de predicci\u00f3n de resistencia y\/o susceptibilidad al tratamiento de la cohorte de pacientes a estudio. Para ello se realiz\u00f3 tipificaci\u00f3n de los alelos dr mediante t\u00e9cnicas de baja resoluci\u00f3n y de los alelos dqb1 y dqa1 as\u00ed como de los subtipos antig\u00e9nicos de dr2 mediante t\u00e9cnicas de alta resoluci\u00f3n por pcr-ssop.  los resultados de los estudios poblacionales realizados desde el punto de vista genot\u00edpico, fueron que los alelos drb1*12 y drb1*10 se expresaban con una frecuencia mayor en la poblaci\u00f3n de pacientes con pti comparado con ambas poblaciones control, resultando estad\u00edsticamente significativa esta expresi\u00f3n.  posteriormente y analizando individualmente los dos subrupos de la cohorte de pacientes con pti se objetiva que los alelos dr2 y dr4 se expresan de manera aumentada en el subgrupo de pacientes refractarios a<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del sistema hla en la p\u00farpura trombocitopenica idiop\u00e1tica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del sistema hla en la p\u00farpura trombocitopenica idiop\u00e1tica <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Paz Arias Raquel De <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Rodr\u00edguez Montes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Armalicia fernandez <\/li>\n<li>Fernando Ramos ortega (vocal)<\/li>\n<li>Fernando Gilsasnz rodr\u00edguez (vocal)<\/li>\n<li> G\u00f3mez de la concha Emilio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paz Arias Raquel De La p\u00farpura trombocitop\u00e9nica idiop\u00e1tica es un trastorno inmunol\u00f3gico caracterizado por la puesta en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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