{"id":30342,"date":"2018-03-09T09:23:54","date_gmt":"2018-03-09T09:23:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-comparativo-de-la-modulacion-de-la-neurotransmision-noradrenergica-por-farmacos-antidepresivos-en-rata\/"},"modified":"2018-03-09T09:23:54","modified_gmt":"2018-03-09T09:23:54","slug":"estudio-comparativo-de-la-modulacion-de-la-neurotransmision-noradrenergica-por-farmacos-antidepresivos-en-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/estudio-comparativo-de-la-modulacion-de-la-neurotransmision-noradrenergica-por-farmacos-antidepresivos-en-rata\/","title":{"rendered":"Estudio comparativo de la modulaci\u00f3n de la neurotransmisi\u00f3n noradren\u00e9rgica por f\u00e1rmacos antidepresivos en rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Laura Grandoso Ferreras <\/strong><\/h2>\n<p>Los f\u00e1rmacos antidepresivos incremental la disponibilidad de la serotonina y\/o noradrenalina sin\u00e1ptica, todav\u00eda no se ha explicado porqu\u00e9 dichos f\u00e1rmacos no ejercen su efecto terap\u00e9utico hasta dos o tres semanas tras el tratamiento. en este estudio vamos a utilizar el locus coeruleus que contiene neuronas noradren\u00e9rgicas y recibe aferencias seroton\u00e9rgicas. Tambi\u00e9n vamos a utilizar el conducto deferente de la rata contiene una gran cantidad de adrenoceptores a2 y constituye un buen modelo para estudiar los cambios en la sensibilidad de estos receptores adren\u00e9rgicos. En este estudio hemos observado, que la 5-ht inhibe la contracci\u00f3n del conducto deferente y produce una disminuci\u00f3n de la sensibilidad de los adrenoceptores a2. Adem\u00e1s, la estimulaci\u00f3n prolongada de la s\u00edntesis de 5-ht, provoca un aumento y la inhibici\u00f3n de la s\u00edntesis de 5-ht induce una disminuci\u00f3n de la sensibilidad de los adrenoceptores a2 en el conducto deferentes de rata. Por otro lado, el citalopram inhibe la actividad de las neuronas del locus coeruleus a trav\u00e9s de varios emcanismos. tanto la aplicaci\u00f3n de 5-ht como de otros f\u00e1rmacos inhibidores selectivos de la recaptaci\u00f3n de serotonina inhiben la actividad de las neuronas del locus coeruleus de la misma forma que el citalopram, lo que confirma el papel inhibitorio directo de la 5-ht en este n\u00facleo. El tratamiento de manera repetida con desipramina y reboxetina produce un aumento de la sensiblidad a la desipramina pero no producen ninguna variaci\u00f3n en la sensibilidad a la reboxetina en las neuronas del locus coeruleus.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio comparativo de la modulaci\u00f3n de la neurotransmisi\u00f3n noradren\u00e9rgica por f\u00e1rmacos antidepresivos en rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio comparativo de la modulaci\u00f3n de la neurotransmisi\u00f3n noradren\u00e9rgica por f\u00e1rmacos antidepresivos en rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Laura Grandoso Ferreras <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luisa Ugedo Urruela<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: isabel (secretario) Ulibarri marcos <\/li>\n<li>\u00e1ngel Pazos carro (vocal)<\/li>\n<li> Mic\u00f3 segura Juan  Antonio (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Laura Grandoso Ferreras Los f\u00e1rmacos antidepresivos incremental la disponibilidad de la serotonina y\/o noradrenalina sin\u00e1ptica, todav\u00eda no [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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