{"id":30368,"date":"2018-03-09T09:23:57","date_gmt":"2018-03-09T09:23:57","guid":{"rendered":""},"modified":"2018-03-09T09:23:57","modified_gmt":"2018-03-09T09:23:57","slug":"epidemiologa%c2%ada-genetica-del-cancer-ligado-a-brca1-brca2-y-otros-genes-de-susceptibilidad-al-cancer-de-mama-en-el-paa%c2%ads-vasco-estudio-basado-en-analisis-de-la-estructura-genetica-mediante-i","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/epidemiologa%c2%ada-genetica-del-cancer-ligado-a-brca1-brca2-y-otros-genes-de-susceptibilidad-al-cancer-de-mama-en-el-paa%c2%ads-vasco-estudio-basado-en-analisis-de-la-estructura-genetica-mediante-i\/","title":{"rendered":"Epidemiolog\u00eda gen\u00e9tica del c\u00e1ncer ligado a brca1, brca2 y otros genes de susceptibilidad al c\u00e1ncer de mama en el pa\u00eds vasco: estudio basado en an\u00e1lisis de la estructura gen\u00e9tica mediante isonimia."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jes\u00fas Delgado Naranjo <\/strong><\/h2>\n<p>Introducci\u00f3n, antecedentes y estado actual del tema  el c\u00e1ncer de mama es un problema de primera magnitud en medicina preventiva y salud p\u00fablica. Adem\u00e1s de brca1 y brca2, numerosos genes de susceptibilidad al c\u00e1ncer de mama han sido descritos, siendo sus frecuencias desconocidas hasta la fecha en la poblaci\u00f3n del pa\u00eds vasco. A su vez estos genes aparecen asociados a m\u00faltiples localizaciones anat\u00f3micas adem\u00e1s de la mama. En este contexto, urge identificar qu\u00e9 genes y qu\u00e9 modelos gen\u00e9ticos operan mayoritariamente en el pa\u00eds vasco, definiendo las localizaciones anat\u00f3micas y variables asociadas a tener en cuenta en futuros estudios epidemiol\u00f3gicos.  material y m\u00e9todos  bajo el sustrato metodol\u00f3gico de la isonimia -an\u00e1lisis gen\u00e9tico poblacional mediante apellidos- se analizaron un total de 12.046 mujeres diagnosticadas de c\u00e1ncer de mama y en otras 20 localizaciones anat\u00f3micas incluidas en el registro de c\u00e1ncer de euskadi entre 1986 y 1992. Dichos resultados fueron comparados con una muestra de 151.721 mujeres pertenecientes a poblaci\u00f3n general procedente de euskadi. El m\u00e9todo fue el de an\u00e1lisis de parentesco gen\u00e9tico de morton (relethford, 1988).  resultados y conclusiones  el an\u00e1lisis comparativo entre poblaci\u00f3n general y oncol\u00f3gica revela que las mayores diferencias se aprecian en mama, cuello uterino, enc\u00e9falo y \u00fatero. El an\u00e1lisis de distancia entre localizaciones anat\u00f3micas revela dos clusters principales: uno en torno a mama, vesicula, colon cervix y enc\u00e9falo -todas ellas con un parentesco gen\u00e9tico superior al de la poblaci\u00f3n general- y el otro en torno a ovario, \u00fatero, p\u00e1ncreas, pulm\u00f3n y sangre todas ellas con un parentesco gen\u00e9tico gen\u00e9tico inferior al de la poblaci\u00f3n general. Las localizaciones anat\u00f3micas probablemente ligadas a brca1 y brca2 son: mama, ovario, colon, cuello uterino y enc\u00e9falo. Los resultados son compatibles con genes exclusivos de susceptibilidad al c\u00e1ncer de est\u00f3mago<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Epidemiolog\u00eda gen\u00e9tica del c\u00e1ncer ligado a brca1, brca2 y otros genes de susceptibilidad al c\u00e1ncer de mama en el pa\u00eds vasco: estudio basado en an\u00e1lisis de la estructura gen\u00e9tica mediante isonimia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Epidemiolog\u00eda gen\u00e9tica del c\u00e1ncer ligado a brca1, brca2 y otros genes de susceptibilidad al c\u00e1ncer de mama en el pa\u00eds vasco: estudio basado en an\u00e1lisis de la estructura gen\u00e9tica mediante isonimia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jes\u00fas Delgado Naranjo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Rodr\u00edguez Andr\u00e9s<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Sanz aguado M\u00aa adela <\/li>\n<li> Tejada m\u00edngez M\u00aa isabel (vocal)<\/li>\n<li>Luis Serra camo (vocal)<\/li>\n<li>feliciano Jes\u00fas Ramos fuentes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jes\u00fas Delgado Naranjo Introducci\u00f3n, antecedentes y estado actual del tema el c\u00e1ncer de mama es un problema [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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