{"id":30394,"date":"2018-03-09T09:23:59","date_gmt":"2018-03-09T09:23:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-hemodinamicas-y-metabolicas-en-el-xenotrasplante-ortotopico-hepatico-modelo-de-cerdo-a-babuino\/"},"modified":"2018-03-09T09:23:59","modified_gmt":"2018-03-09T09:23:59","slug":"alteraciones-hemodinamicas-y-metabolicas-en-el-xenotrasplante-ortotopico-hepatico-modelo-de-cerdo-a-babuino","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/murcia\/alteraciones-hemodinamicas-y-metabolicas-en-el-xenotrasplante-ortotopico-hepatico-modelo-de-cerdo-a-babuino\/","title":{"rendered":"Alteraciones hemodin\u00e1micas y metab\u00f3licas en el xenotrasplante ortot\u00f3pico hep\u00e1tico. modelo de cerdo a babuino."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Garc\u00eda Palenciano <\/strong><\/h2>\n<p>En los \u00faltimos a\u00f1os la carencia de \u00f3rganos para transplante de \u00f3rganos ha llevado a un renovado inter\u00e9s por el uso de \u00f3rganos animales como una de las posibles v\u00edas para solucionarlo. La carencia de \u00f3rganos es tal que, seg\u00fan c\u00e1lculos de la organizaci\u00f3n nacional de trasplantes, ser\u00eda necesario duplicar la cifra actual de donantes para que todos los pacientes de la lista de espera recibieran un trasplante. Sin embargo en los \u00faltimos a\u00f1os la cifra de donantes se ha estancado en torno a los 33 donantes por mill\u00f3n de habitantes.  existe conseso en considerar al cerdo como el animal de elecci\u00f3n para donar \u00f3rganos destinados a trasplantes, puesto que es un animal abundante,f\u00e1cil de criar y que no suscrita preocupaciones \u00e9ticas puesto que se usa ampliamente para alimentaci\u00f3n. Sin embargo presenta la dificultad de que cuando un \u00f3rgano porcino se injerta en el entorno de un primate sufre un rechazo hiperagudo y es destruido en el plazo de minutos. Por este motivo hasta hace a\u00f1os no se planteaba la posibilidad de usarlo como donante de \u00f3rganos, perodesde hace alg\u00fan tiempo se dispone de cerdos transg\u00e9nicos para daf(decay acceleration factor) humano y otras prote\u00ednas reguladoras del complemento, en el que se ha controlado el rechazo hiperagudo en modelos experimentales de xenotrasplante renal y cardiaco de cerdo a babuino, aunque la experiencia en xenotrasplante hep\u00e1tico de cerdo o primate no humano es muy limitada.  la hip\u00f3tesis de trabajo de la tesis es que el h\u00edgado de cerdo transg\u00e9nico para las prote\u00ednas reguladores del complemento humano, trasplantado en un babuino, al no presentar un rechazo hiperagudo al igual que ocurre con el coraz\u00f3n y ri\u00f1\u00f3n, permitir\u00e1 un mejor control hemodin\u00e1mico y metab\u00f3lico, durante y tras el procedimiento quir\u00fargico, que cuando se trasplanta un \u00f3rgano no modificado, y por lo tanto tendr\u00e1 m\u00e1s posibilidades de mantener con vida al receptor.  objetivos de la tesis:  1) comprobar<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones hemodin\u00e1micas y metab\u00f3licas en el xenotrasplante ortot\u00f3pico hep\u00e1tico. modelo de cerdo a babuino.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones hemodin\u00e1micas y metab\u00f3licas en el xenotrasplante ortot\u00f3pico hep\u00e1tico. modelo de cerdo a babuino. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Garc\u00eda Palenciano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pablo Ram\u00edrez Romero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ricardo Robles campos <\/li>\n<li>Jos\u00e9 Mir pallard\u00f3 (vocal)<\/li>\n<li>Antonio Mu\u00f1oz luna (vocal)<\/li>\n<li>antoni Sabat\u00e9 pes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Garc\u00eda Palenciano En los \u00faltimos a\u00f1os la carencia de \u00f3rganos para transplante de \u00f3rganos ha llevado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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