{"id":30399,"date":"2018-03-09T09:24:00","date_gmt":"2018-03-09T09:24:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/hipotiroidismo-y-sa%c2%adndrome-del-aceite-toxico\/"},"modified":"2018-03-09T09:24:00","modified_gmt":"2018-03-09T09:24:00","slug":"hipotiroidismo-y-sa%c2%adndrome-del-aceite-toxico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/hipotiroidismo-y-sa%c2%adndrome-del-aceite-toxico\/","title":{"rendered":"Hipotiroidismo y s\u00edndrome del aceite t\u00f3xico"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Plaza Cano M. Mar <\/strong><\/h2>\n<p>Introducci\u00f3n  el s\u00edndrome del aceite t\u00f3xico (sat) es una enfermedad multisist\u00e9mica, epid\u00e9mica, como consecuencia de una intoxicaci\u00f3n alimentaria por aceite adulterado, ocurrida en espa\u00f1a en 1981. La lesi\u00f3n histol\u00f3gica b\u00e1sica es una endovasculitis. en su patogenia intervienen factores toxicol\u00f3gicos, inmunol\u00f3gicos y gen\u00e9ticos. se estudia la afectaci\u00f3n tiroidea.  material y m\u00e9todos  en la unidad cl\u00ednica del cisater (centro de investigaci\u00f3n del s\u00edndrome del aceite t\u00f3xico enfermedades raras), de Madrid se estudi\u00f3, con revisiones anuales protocolizadas, una cohorte de 1165 afectados de sat (809 mujeres), de edad media 48,5 a\u00f1os, que cumpl\u00edan los criterios diagn\u00f3sticos y estaban incluidos en el censo oficial revcen, entre diciembre de 1997 a octubre de 2000. Como poblaci\u00f3n de referencia se tom\u00f3 una muestra estratificada de 110 pacientes no afectados por sat apareados por edad sexo y localidad geogr\u00e1fica, que fueron evaluados de igual manera que la cohorte. Se determinaron anal\u00edtica general, t4 libre, tsh, gab, pruebas de funci\u00f3n respiratoria, ecg y radiograf\u00eda de t\u00f3rax. En algunos casos se realiz\u00f3 ecocardiograma o ecograf\u00eda tiroidea. Se analiz\u00f3 la preValencia de hipotiroidismo en la cohorte y en la poblaci\u00f3n de referencia (descart\u00e1ndose para el an\u00e1lisis aquellos casos de hipotiroidismo secundarios a cirug\u00eda, radioterap\u00eda, tratamientos farmacol\u00f3gicos, enfermedades o gen\u00e9ticos). Se realiz\u00f3 una revisi\u00f3n bibliogr\u00e1fica de la preValencia del hipotiroidismo en la poblaci\u00f3n general.  se hizo un estudio inmunol\u00f3gico (ac antitpo, ac antitiroglobulina, ana, ena), y  gen\u00e9tico (regiones dr y dq del ant\u00edgeno de histocompatibilidad mayor -hla-) a los casos de sat con hipotiroidismo y a una muestra control de pacientes de sat sin hipotiroidismo, obtenida aleatoriamente del conjunto de la cohorte, apareada por edad y sexo. Se seleccionaron dos controles por caso para el an\u00e1lisis inmunol\u00f3gico y un socio control<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Hipotiroidismo y s\u00edndrome del aceite t\u00f3xico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Hipotiroidismo y s\u00edndrome del aceite t\u00f3xico <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Plaza Cano M. Mar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>medel Palacio P\u00e9rez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Enr\u00edquez de salamanca <\/li>\n<li>julio De la morena fern\u00e1ndez (vocal)<\/li>\n<li>mart\u00edn S\u00e1nchez franco (vocal)<\/li>\n<li>c\u00e1ndido Vazquez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Plaza Cano M. Mar Introducci\u00f3n el s\u00edndrome del aceite t\u00f3xico (sat) es una enfermedad multisist\u00e9mica, epid\u00e9mica, como [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[85440,5696,17534,44349,85439,23210],"class_list":["post-30399","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-candido-vazquez","tag-julio-de-la-morena-fernandez","tag-martin-sanchez-franco","tag-medel-palacio-perez","tag-plaza-cano-m-mar","tag-rafael-enriquez-de-salamanca"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30399","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=30399"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30399\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=30399"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=30399"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=30399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}