{"id":30405,"date":"2018-03-09T09:24:00","date_gmt":"2018-03-09T09:24:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-nitrergica-de-la-funcion-motora-gastrointestinal-en-la-endotoxema%c2%ada\/"},"modified":"2018-03-09T09:24:00","modified_gmt":"2018-03-09T09:24:00","slug":"regulacion-nitrergica-de-la-funcion-motora-gastrointestinal-en-la-endotoxema%c2%ada","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-nitrergica-de-la-funcion-motora-gastrointestinal-en-la-endotoxema%c2%ada\/","title":{"rendered":"Regulaci\u00f3n nitr\u00e9rgica de la funci\u00f3n motora gastrointestinal en la endotoxem\u00eda"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elsa Quintana Fern\u00e1ndez <\/strong><\/h2>\n<p>En la fase aguda de una infecci\u00f3n bacteriana  se observa una alteraci\u00f3n dela funci\u00f3n motor gastrointestinal caracterizada por una hipocontractilidad del est\u00f3mago proximal, inhibici\u00f3n del vaciamiento g\u00e1strico y acelaraci\u00f3n intestinal.  en la presente tesis hemos analizado los mecanismos responsables de dicha alteraci\u00f3n durante los estadios iniciales de la endoteoxemia en la rata.  hemos demostrado que todos cambios se producen r\u00e1pidamente gracias a la actuaci\u00f3n del sistema nervioso, tanto central como perif\u00e9rico. As\u00ed, los efectos de la endotoxina est\u00e1n mediados por la activaci\u00f3n de las neuronas aferentes sensoriales sensibles a la capsaicina, que env\u00edan la se\u00f1al de \u00abalerta\u00bb al sistema nervioso central donde r\u00e1pidamente se procesa la informaci\u00f3n y posteriormente se activan fibras eferentes vagales que est\u00e1n en \u00edntimo contacto con el sistema nervioso ent\u00e9rico, modulando finalmente la motilidad gastrointestinal.  adem\u00e1s, la regulaci\u00f3n post-transcripcional de la enzima \u00f3xido n\u00edtrico sintasa neuronal tiene un papel protagonista en todo este proceso. Un incremento de la s\u00edntesis de \u00f3xido n\u00edtrico en el tronco de enc\u00e9falo, en neuronas post-ganglionares del plexo mient\u00e9rico del est\u00f3mago proximal y en la pared col\u00f3nica sucede en los primeros estadios de la endotoxemia.Pasado el efecto agudo de la endotoxina, empezar\u00edan a observase lo que se considera parte de una respuesta inmune generalizada que requiere m\u00e1s tiempo para alcanzar la plena actividad, por ejemplo la expresi\u00f3n de las enzimas \u00f3xido n\u00edtrico sintasa inducible o cilooxigenasa-2. Parece que en respuesta a una invasi\u00f3n bacteriana, el organismo maximiza la actividad de sus recursos fisiol\u00f3gicos mientras se alcanza la plena actividad del sistema inmune.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n nitr\u00e9rgica de la funci\u00f3n motora gastrointestinal en la endotoxem\u00eda<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n nitr\u00e9rgica de la funci\u00f3n motora gastrointestinal en la endotoxem\u00eda<\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elsa Quintana Fern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Esplugues Mota Juan  Vicente<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: esteban Morcillo s\u00e1nchez <\/li>\n<li>Alberto Alvarez barrientos (vocal)<\/li>\n<li>Miguel Bixquert jim\u00e9nez (vocal)<\/li>\n<li>Juli\u00e1n Pan\u00e9s d\u00edaz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elsa Quintana Fern\u00e1ndez En la fase aguda de una infecci\u00f3n bacteriana se observa una alteraci\u00f3n dela funci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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