{"id":30412,"date":"2018-03-09T09:24:01","date_gmt":"2018-03-09T09:24:01","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-estructura-funcion-sobre-la-enzima-aril-alcohol-oxidasa-implicada-en-la-biodegradacion-de-la-lignina\/"},"modified":"2018-03-09T09:24:01","modified_gmt":"2018-03-09T09:24:01","slug":"estudios-estructura-funcion-sobre-la-enzima-aril-alcohol-oxidasa-implicada-en-la-biodegradacion-de-la-lignina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/alcala\/estudios-estructura-funcion-sobre-la-enzima-aril-alcohol-oxidasa-implicada-en-la-biodegradacion-de-la-lignina\/","title":{"rendered":"Estudios estructura\/funcion sobre la enzima aril alcohol oxidasa implicada en la biodegradacion de la lignina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Patricia Ferreira Neila <\/strong><\/h2>\n<p>La biodegradaci\u00f3n de la lignina es un proceso oxidativo, llevado a cabo por los denominados hongos de podredumbre blanca. El per\u00f3xido de hidrogeno tiene un importante papel en este proceso como precursor del radical libre hidroxilo y co-sustrato de peroxidasas ligninol\u00edticas. La aril-alcohol oxidasa (aao) de pleurotus eryngii es una flavoprote\u00edna extracelular que genera h2o2 en la reacci\u00f3n de oxidaci\u00f3n de la enzima por el o2, mientras que su reducci\u00f3n da lugar a reacciones de oxidaci\u00f3n y deshidrogenaci\u00f3n de diferentes alcoholes arom\u00e1ticos. Su reciente clonaci\u00f3n y expresi\u00f3n heter\u00f3loga en emericella nidulans y escherichia coli ha permitido completar la caracterizaci\u00f3n fisicoqu\u00edmica, cin\u00e9tica y estructural de la aao.  los estudios de especificidad de sustrato pusieron de manifiesto que los sustratos t\u00edpicos de la aao son alcoholes arom\u00e1ticos o alif\u00e1ticos poliinsaturados con un hidroxilo primario en el ca. Adem\u00e1s los estudios de inhibici\u00f3n revelaron que la aao tiene afinidad por compuestos con sistemas de dobles enlaces conjugados con o sin grupos hidroxilo alcoh\u00f3licos. Los estudios de cin\u00e9tica r\u00e1pida con diferentes alcoholes pusieron de manifiesto la dependencia de las cin\u00e9ticas de reducci\u00f3n de la aao del tipo sustrato.  la aao presenta una moderada homolog\u00eda de secuencia con la glucosa oxidasa de aspergillus niger lo que permiti\u00f3 su modelado por homolog\u00eda (entrada pdb 1qjn). La comparaci\u00f3n de la estructura primaria de la aao con la glucosa oxidasa y otros miembros de la familia gmc de oxido-reductasas, revel\u00f3 la existencia en la secuencia de la aao de los cuatro motivos conservados en esta familia. Este hecho, junto con las similares caracter\u00edsticas estructurales encontradas, han llevado en este trabajo a incluir a la aao de p. Eryngii como un nuevo miembro de la familia gmc. La arquitectura molecular general de la aao presenta dos dominios estructurales: i) dominio de uni\u00f3n del fad y ii) dominio de uni\u00f3n a<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios estructura\/funcion sobre la enzima aril alcohol oxidasa implicada en la biodegradacion de la lignina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios estructura\/funcion sobre la enzima aril alcohol oxidasa implicada en la biodegradacion de la lignina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Patricia Ferreira Neila <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/05\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Tomas Martinez Ferrer<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: bartolom\u00e9 Sabater Garc\u00eda <\/li>\n<li>guillermo Gimenez gallego (vocal)<\/li>\n<li> Gomez moreno calera Carlos (vocal)<\/li>\n<li>Miguel \u00e1ngel Falc\u00f3n sanabria (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Patricia Ferreira Neila La biodegradaci\u00f3n de la lignina es un proceso oxidativo, llevado a cabo por los 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