{"id":30442,"date":"2004-01-06T00:00:00","date_gmt":"2004-01-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulation-of-spinal-nociception-by-glur5-kainate-receptor-ligands-in-newborn-and-adult-rats\/"},"modified":"2004-01-06T00:00:00","modified_gmt":"2004-01-06T00:00:00","slug":"modulation-of-spinal-nociception-by-glur5-kainate-receptor-ligands-in-newborn-and-adult-rats","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/alcala\/modulation-of-spinal-nociception-by-glur5-kainate-receptor-ligands-in-newborn-and-adult-rats\/","title":{"rendered":"Modulation of spinal nociception by glur5 kainate receptor ligands in newborn and adult rats."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Paula Masc\u00edas N\u00fa\u00f1ez <\/strong><\/h2>\n<p>El receptor glur5 de kainato modula la nocicepcion espinal aunque hay discrepancias en el papel que juega en distintos estadios del desarrollo asi como en diferentes situaciones de excitabilidad. Mediante el empleo de tecnicas comportamentales y electrofisiologicas, en este trabajo hemos investigado el efecto de varios ligandos del receptor glur5 en situacion aguda y en situacion de hiperalgesia, tanto en ratas jovenes como adultas. adem\u00e1s, como el sistema gabaergico esta implicado en los efectos mediados por el receptor glur5 en el cerebro, estudiamos la posible interaccion entre los antagonistas de glur5 y los antagonistas de gabaa en la medula espinal. La distribuci\u00f3n regional y celular de la subunidad glur5 en la medula espinal durante el desarrollo tambien fue analizada.  en experimentos in vitro con m\u00e9dulas de ratas neonatales, los agonistas selectivos del receptor glur5, atpa y (s)-5-iodowillardiine, inhibieron los reflejos nociceptivos evocados por estimulacion el\u00e9ctrica, mientras que el agonista mixto de receptores glur5\/glur6, sym2081 no mostr\u00f3 actividad. ambos agonistas selectivos tambi\u00e9n inhibieron las respuestas a la estimulaci\u00f3n repetitiva de la ra\u00edz dorsal y su despolarizaci\u00f3n acumulada (fen\u00f3meno wind-up). atpa, y no sym2081, fue efectivo en la reducci\u00f3n de respuestas nociceptivas en ratas adultas anestesiadas tras administraci\u00f3n intratecal. La inducci\u00f3n de inflamaci\u00f3n de tejidos blandos redujo la dosis m\u00ednima efectiva de atpa en ratas adultas atpa y sym2081 mostraron efecto antionociceptivo y antihiperalg\u00e9sico en un modelo de hiperalgesia por inflamaci\u00f3n, pero con diferentes perfiles de actividad. Los antagonistas de gabaa biculina y sr95531 atenuaron la inhibici\u00f3n de respuestas nociceptivas producidas por atpa, especialmente en la preparaci\u00f3n in vitro de hemim\u00e9dula.  en experimentos de inmunohistoqu\u00edmica, se observ\u00f3 que la subunidad glur5 se expresa en la m\u00e9dula espinal de ratas j\u00f3venes y adultas,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulation of spinal nociception by glur5 kainate receptor ligands in newborn and adult rats.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulation of spinal nociception by glur5 kainate receptor ligands in newborn and adult rats. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Paula Masc\u00edas N\u00fa\u00f1ez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Fernando Herrero  Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis fernando Alguacil merino <\/li>\n<li>teresa Fern\u00e1ndez agull\u00f3 (vocal)<\/li>\n<li>Carlos Goicoechea garcia (vocal)<\/li>\n<li>lidia Morales goyanes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paula Masc\u00edas N\u00fa\u00f1ez El receptor glur5 de kainato modula la nocicepcion espinal aunque hay discrepancias en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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