{"id":30444,"date":"2004-01-06T00:00:00","date_gmt":"2004-01-06T00:00:00","guid":{"rendered":""},"modified":"2004-01-06T00:00:00","modified_gmt":"2004-01-06T00:00:00","slug":"sintesis-y-evaluacion-biologica-de-24-dinamio-5-nitrosopirimidas-como-inhibidores-de-alquilguanina-adn-alquiltransferasa-humana-hagt-estudio-estructural-molecular-y-supramolecular-mediante-difracc","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/jaen\/sintesis-y-evaluacion-biologica-de-24-dinamio-5-nitrosopirimidas-como-inhibidores-de-alquilguanina-adn-alquiltransferasa-humana-hagt-estudio-estructural-molecular-y-supramolecular-mediante-difracc\/","title":{"rendered":"Sintesis y evaluaci\u00f3n biol\u00f3gica de 2,4-dinamio-5-nitrosopirimidas como inhibidores de alquilguanina adn alquiltransferasa humana (hagt). estudio estructural molecular y supramolecular mediante difracci\u00f3n de rayos x. asdfasasdfasdf"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Quesada Armenteros <\/strong><\/h2>\n<p>Mediante la metodolog\u00eda de nitrosaci\u00f3n selectiva en el c(5) de aminoalcoxipirimidinas y posterior aminolisis sobre la 2-amin0-4,6(bis)bendloxi-s-nitrosopirimidina se ha propuesto la s\u00edntesis de posibles inhibidores de agt (alquilguanina-and-alquiltransferasa humana), basados en el n\u00fadeo de 2,4-diamino- 6-bendloxi-5-nitrosopirimidina. La elecci\u00f3n de las aminas ensayadas en las reacciones de aminolisis, se ha llevado a cabo en fundon de las modificadones que presentan en la cadena alqumca, entre las que caben destacar: sustituyentes arom\u00e1ticos (anilina), diversas ramificadones en posidones alfa, beta \u00f3 gamma de la cadena alqu\u00edlica; cadenas de diferente longitud( metil, butil y dodecil), as\u00ed como de la disponibilidad comerdal de las mismas. La metodolog\u00eda encontrada para las reacciones de aminolisis se caracteriza fundamentalmente por las suaves condiciones bajo las que se produce la sustitud\u00f3n del grupo bendloxi tales como la baja basicidad, temperaturas moderadas (entre 25-60 0c) ylos buenos rendimientos obtenidos. los compuestos obtenidos en las distintas etapas de s\u00edntesis de productos de partida, compuestos nitrosados y compuestos sometidos a las reacciones de aminolisis han sido caracterizados mediante distintas t\u00e9cnicas espectrosc\u00f3picas, como la rmnde lh, 13c y 14n, infrarojos, ultravioleta-visible y espectrometr\u00eda de masas. se ha dedicado un cap\u00edtuo \u00edntegro al an\u00e1lisis estructural mediante los datos obtenidos de difracci\u00f3n de rayos x en monoaistal de los nitrosoderivados, algunos de sus precursores y\/o an\u00e1logos. La utilizaci\u00f3n de esta t\u00e9cnica y el gran n\u00famero de estructuras resueltas nos ha permitido realizar un detallado an\u00e1lisis estructural molecular y supramolecular hadendo uso de los \u00f3rdenes de enlace y la teor\u00eda de grafos, permitiendo establecer patrones electr\u00f3nicos moleculares para los distintos tipos de nitrosopirimidinas estudiados.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis y evaluaci\u00f3n biol\u00f3gica de 2,4-dinamio-5-nitrosopirimidas como inhibidores de alquilguanina adn alquiltransferasa humana (hagt). estudio estructural molecular y supramolecular mediante difracci\u00f3n de rayos x. asdfasasdfasdf<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis y evaluaci\u00f3n biol\u00f3gica de 2,4-dinamio-5-nitrosopirimidas como inhibidores de alquilguanina adn alquiltransferasa humana (hagt). estudio estructural molecular y supramolecular mediante difracci\u00f3n de rayos x. asdfasasdfasdf <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Quesada Armenteros <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Ja\u00e9n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Melguizo Guijarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: adolfo Sanchez rodrigo <\/li>\n<li> Sainz d\u00edaz claro ignacio (vocal)<\/li>\n<li>n. Low john (vocal)<\/li>\n<li> Plaza l\u00f3pez-espinosa Mar\u00eda  teresa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Quesada Armenteros Mediante la metodolog\u00eda de nitrosaci\u00f3n selectiva en el c(5) de aminoalcoxipirimidinas y posterior aminolisis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[18923],"tags":[3854,85535,39527,85537,85538,85536],"class_list":["post-30444","post","type-post","status-publish","format-standard","hentry","category-jaen","tag-adolfo-sanchez-rodrigo","tag-antonio-quesada-armenteros","tag-manuel-melguizo-guijarro","tag-n-low-john","tag-plaza-lopez-espinosa-maria-teresa","tag-sainz-diaz-claro-ignacio"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30444","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=30444"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30444\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=30444"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=30444"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=30444"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}