{"id":30480,"date":"2004-03-06T00:00:00","date_gmt":"2004-03-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-del-receptor-de-insulina-y-de-su-sustrato-irs-4-en-diferentes-modelos-de-proliferacion-hepatica\/"},"modified":"2004-03-06T00:00:00","modified_gmt":"2004-03-06T00:00:00","slug":"implicacion-del-receptor-de-insulina-y-de-su-sustrato-irs-4-en-diferentes-modelos-de-proliferacion-hepatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/alcala\/implicacion-del-receptor-de-insulina-y-de-su-sustrato-irs-4-en-diferentes-modelos-de-proliferacion-hepatica\/","title":{"rendered":"Implicaci\u00f3n del receptor de insulina y de su sustrato (irs-4) en diferentes modelos de proliferaci\u00f3n hep\u00e1tica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Oscar Escribano Illanes <\/strong><\/h2>\n<p>En la presente tesis se analiza el papel de la insulina y de su sustrato irs-4 en los procesos de proliferaci\u00f3n y diferenciaci\u00f3n hep\u00e1tica.  en la primera parte de esta tesis se ha estudiado el efecto del tacrolimus (fk506), un inmunosupresor ampliamente utilizado en cl\u00ednica, sobre la expresi\u00f3n del receptor de insulina hep\u00e1tico durante el proceso de  regeneraci\u00f3n que sigue a una hepatectom\u00eda parcial. Con los resultados obtenidos, se demuestra que el pretratamiento con el f\u00e1rmaco induce un incremento en la regeneraci\u00f3n hep\u00e1tica, al menos en parte, debido a un aumento en la expresi\u00f3n del receptor de insulina, lo que de forma concomitante induce un incremento en la sensibilidad de los hepatocitos regenerantes a esta hormona. Este resultado es de una gran relevancia a la hora de analizar la trascendencia del pretratamiento con fk506 en la evoluci\u00f3n de los transplantes de h\u00edgado segmentario.  en segundo lugar, se caracteriza por primera vez, la expresi\u00f3n de irs-4 (insulin receptor substrate-4) en h\u00edgado de rata, as\u00ed como la activaci\u00f3n de esta prote\u00edna en respuesta a insulina e igf-i (insulin-like growth factor-i). adem\u00e1s, se demuestra la inducci\u00f3n de esta prote\u00edna durante el proceso de regeneraci\u00f3n hep\u00e1tica, lo que sugiere un importante papel de esta prote\u00edna en este proceos.  por \u00faltimo, en la presente tesis se demuestra la expresi\u00f3n de irs-4 en hep g2, una l\u00ednea celular procedente de un hepatoblastoma humano. En esta l\u00ednea celular se demuestra que el silenciamiento del gen de irs-4 mediante la t\u00e9cnica del arn de interferencia, induce importantes cambios morfol\u00f3gicos, inhibe la proliferaci\u00f3n celular e incrementa la sensibilidad de estas c\u00e9lulas a agentes proapopt\u00f3ticos como tnf-a m\u00e1s actinomicina d. Este \u00faltimo hallazgo puede tener importantes repercusiones cl\u00ednicas, ya que la sensibilizaci\u00f3n de c\u00e9lulas tumorales a tnf-a, por la depleci\u00f3n de irs-4, puede constituir una nueva estrategia terap\u00e9utica en e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n del receptor de insulina y de su sustrato (irs-4) en diferentes modelos de proliferaci\u00f3n hep\u00e1tica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n del receptor de insulina y de su sustrato (irs-4) en diferentes modelos de proliferaci\u00f3n hep\u00e1tica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Oscar Escribano Illanes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Alberto Gonz\u00e1lez Guijarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: emilio Herrera castillon <\/li>\n<li>Mar\u00eda  isabel Fabregat romero (vocal)<\/li>\n<li>eduardo Arilla ferreiro (vocal)<\/li>\n<li>Manuel roman Benito de las heras (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Oscar Escribano Illanes En la presente tesis se analiza el papel de la insulina y de su [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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