{"id":30503,"date":"2004-04-06T00:00:00","date_gmt":"2004-04-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-alteraciones-fisiologicas-y-moleculares-asociadas-al-comportamiento-de-celulas-madre-hematopoyeticas-en-ratones-deficientes-en-il-6\/"},"modified":"2004-04-06T00:00:00","modified_gmt":"2004-04-06T00:00:00","slug":"caracterizacion-de-alteraciones-fisiologicas-y-moleculares-asociadas-al-comportamiento-de-celulas-madre-hematopoyeticas-en-ratones-deficientes-en-il-6","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-alteraciones-fisiologicas-y-moleculares-asociadas-al-comportamiento-de-celulas-madre-hematopoyeticas-en-ratones-deficientes-en-il-6\/","title":{"rendered":"Caracterizaci\u00f3n de alteraciones fisiol\u00f3gicas y moleculares asociadas al comportamiento de c\u00e9lulas madre hematopoy\u00e9ticas en ratones deficientes en il-6"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rodr\u00edguez De Miguel M. Carmen <\/strong><\/h2>\n<p>La interleuquina-6 (il-6) es una citoquina implicada en las etapas tempranas del desarrollo linfohematopoy\u00e9tico. Partiendo de un modelo knock-out (ko) para il-6 (il-6-\/-), el cual parece tener comprometida la capacidad de automantenimiento de sus c\u00e9lulas madre o stem, se ha llevado a cabo un estudio detallado de las alteraciones fisiol\u00f3gicas tanto de las c\u00e9lulas precursoras del estroma, soporte de la hematopoyesis, como de las c\u00e9lulas madre hematopoy\u00e9ticas fetales. Se ha detectado una disminuci\u00f3n en el n\u00famero de precursores fibrobl\u00e1sticos (cfu-f y sic) en las m\u00e9dulas correspondientes a ratones deficientes en il-6 y una perdida de expresi\u00f3n de integrinas como alfa-6 y beta-1 o de mol\u00e9culas de ahesi\u00f3n como vcam-1. Los estudios llevados a cabo con c\u00e9lulas de h\u00edgados fetales de 14 d\u00edas correspondientes a ratones deficientes en il-6 han permitido establecer que aunque el comportamiento ltrsc no parece estar disminuido, presenta una menor capacidad de automantenimiento, mientras que si se ha observado una disminuci\u00f3n en el n\u00famero de cfu-f. todo ello parece indicar que il-6 es un factor relevante para c\u00e9lulas hematopoy\u00e9ticas embrionarias y para los precursores mesenquimales del estroma tanto adulto como embrionario. Por \u00faltimo se ha detectado un gran n\u00famero de genes diferencialmente expresados entre precursores primitivos de m\u00e9dula \u00f3sea il-6-\/- e il-6+\/+,. se ha caracterizado 5 de estas secuencias como dnas gen\u00f3micos de rat\u00f3n, una de ellas correspondiente  a alfa-nac, prote\u00edna que parece encontrarse bajo el control transcripcional de il-6 en los diversos tejidos analizados.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de alteraciones fisiol\u00f3gicas y moleculares asociadas al comportamiento de c\u00e9lulas madre hematopoy\u00e9ticas en ratones deficientes en il-6<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de alteraciones fisiol\u00f3gicas y moleculares asociadas al comportamiento de c\u00e9lulas madre hematopoy\u00e9ticas en ratones deficientes en il-6 <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rodr\u00edguez De Miguel M. Carmen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Bernad<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: antonia Lizarbe Mar\u00eda <\/li>\n<li> Barbero esteban Jos\u00e9 Luis (vocal)<\/li>\n<li>Juan  Antonio Bueren roncero (vocal)<\/li>\n<li> Mellado Garc\u00eda Jos\u00e9 mario (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rodr\u00edguez De Miguel M. Carmen La interleuquina-6 (il-6) es una citoquina implicada en las etapas tempranas del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[85677,85676,85678,17439,81566,85675],"class_list":["post-30503","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-antonia-lizarbe-maria","tag-antonio-bernad","tag-barbero-esteban-jose-luis","tag-juan-antonio-bueren-roncero","tag-mellado-garcia-jose-mario","tag-rodriguez-de-miguel-m-carmen"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30503","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=30503"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30503\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=30503"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=30503"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=30503"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}