{"id":30535,"date":"2004-04-06T00:00:00","date_gmt":"2004-04-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/validacion-del-test-de-activacion-de-basofilos-en-alergia-a-pirazalonas-e-intolerancia-a-antiinflamatorios-no-esteroideos\/"},"modified":"2004-04-06T00:00:00","modified_gmt":"2004-04-06T00:00:00","slug":"validacion-del-test-de-activacion-de-basofilos-en-alergia-a-pirazalonas-e-intolerancia-a-antiinflamatorios-no-esteroideos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/validacion-del-test-de-activacion-de-basofilos-en-alergia-a-pirazalonas-e-intolerancia-a-antiinflamatorios-no-esteroideos\/","title":{"rendered":"Validaci\u00f3n del test de activaci\u00f3n de bas\u00f3filos en alergia a pirazalonas e intolerancia a antiinflamatorios no esteroideos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Caballero Gab\u00e1s M. Rosario <\/strong><\/h2>\n<p>Introducci\u00f3n  los antiinflamatorios no esteroideos (aines), son la primera causa de reacciones de intolerancia a f\u00e1rmacos, y la segunda de reacciones al\u00e9rgicas tras los antibi\u00f3ticos betalact\u00e1micos. Hasta el momento, no existe ninguna t\u00e9cnica de diagn\u00f3stico in vitro como prueba complementaria para su estudio.  hip\u00f3tesis y objetivos  ante la ausencia de pruebas in vitro, decidimos validar la utilidad de dos nuevas t\u00e9cnicas: el test de activaci\u00f3n de bas\u00f3filos (tab) y el test de determinaci\u00f3n de sulfidoleucotrienos (cast), as\u00ed como establecer los puntos de corte, comparar con la t\u00e9cnica existentes para cada grupo y valorar su utilidad seg\u00fan el tipo de reacci\u00f3n presentada, el tiempo transcurrido desde la \u00faltima reacci\u00f3n y la condici\u00f3n at\u00f3pica.  material y m\u00e9todos  se realizaron dos grupos de estudio que deb\u00edan cumplir rigurosos criterios de inclusi\u00f3n y exclusi\u00f3n: grupo uno, 26 pacientes con reacci\u00f3n inmediata a pirazolonas y 30 controles, y grupo dos: 60 pacientes diagnosticados de intolerancia a aines y 60 controles, se incluyeron sujetos at\u00f3picos y con asma bronquial extr\u00ednseco para conseguir una muestra heterog\u00e9nea.  resultados  se establecieron los puntos de corte mediante curvas roc siendo para el tab: mayor o igual del  5% de bas\u00f3filos activados y con un \u00edndice de estimulaci\u00f3n (% bas\u00f3filos activados frente al ant\u00edgeno\/ % bas\u00f3filos activados de forma basal) mayor o igual a dos. Para el cast se estableci\u00f3 como: mayor o igual de 100 pg\/ml de sulfidoleucotrienos (slt) liberados y con un \u00edndice de estimulaci\u00f3n mayor o igual a tres. Para el estudio de alergia a pirazolonas (metamizol), el tab present\u00f3 una sensibilidad a (s) de 42,3%, una especificidad (e) de 100%, con un valor predictivo positivo (vpp) de 100% y un valor predictivo negativo (vpn) de 99,4%. El cast present\u00f3 una s de 52%, una e de 90%, un vpp de 5%, y un vpn de 99,3%.  para el estudio de intolerancia a aines testado frente a  \u00e1cid<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Validaci\u00f3n del test de activaci\u00f3n de bas\u00f3filos en alergia a pirazalonas e intolerancia a antiinflamatorios no esteroideos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Validaci\u00f3n del test de activaci\u00f3n de bas\u00f3filos en alergia a pirazalonas e intolerancia a antiinflamatorios no esteroideos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Caballero Gab\u00e1s M. Rosario <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Luisa Sanz Larruga<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jorge  Antonio Guisantes del barco <\/li>\n<li>Jorge Mart\u00ednez quesada (vocal)<\/li>\n<li>alfonso Sanchez ibarrola (vocal)<\/li>\n<li>ignacio Javier Ansotegui zubeldia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Caballero Gab\u00e1s M. Rosario Introducci\u00f3n los antiinflamatorios no esteroideos (aines), son la primera causa de reacciones de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17749],"tags":[13420,85745,51362,17954,29879,51363],"class_list":["post-30535","post","type-post","status-publish","format-standard","hentry","category-navarra","tag-alfonso-sanchez-ibarrola","tag-caballero-gabas-m-rosario","tag-ignacio-javier-ansotegui-zubeldia","tag-jorge-antonio-guisantes-del-barco","tag-jorge-Martinez-quesada","tag-maria-luisa-sanz-larruga"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=30535"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30535\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=30535"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=30535"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=30535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}