{"id":30538,"date":"2004-04-06T00:00:00","date_gmt":"2004-04-06T00:00:00","guid":{"rendered":""},"modified":"2004-04-06T00:00:00","modified_gmt":"2004-04-06T00:00:00","slug":"histiocitoma-fibroso-maligno-de-los-tejidos-blandos-estudio-clinico-patologico-de-85-casos-con-especial-referencia-al-valor-pronostico-del-indice-de-proliferacion-celular-y-de-la-expresion-del-oncoge","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/a-coruna\/histiocitoma-fibroso-maligno-de-los-tejidos-blandos-estudio-clinico-patologico-de-85-casos-con-especial-referencia-al-valor-pronostico-del-indice-de-proliferacion-celular-y-de-la-expresion-del-oncoge\/","title":{"rendered":"Histiocitoma fibroso maligno de los tejidos blandos, estudio clinico patologico de 85 casos con especial referencia al valor pronostico del indice de proliferacion celular y de la expresion del oncogen p53"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Duran Hernandez M. Cristina <\/strong><\/h2>\n<p>En este trabajo de investigaci\u00f3n se estudian 85 casos de histiocitomas fibrosos malignos de los tejidos blandos (hfhs) obtenidos de los archivos de patolog\u00eda del hospital general de galicia y cl\u00ednico universitario de santiago durante 28 a\u00f1os (1974-2002) se realizaron estudios inmunohistoqu\u00edmicos del antigeno nuclear k 67 utilizando el anticuerpo m b1 en 63 casos (4 no valorables) y del oncogen p53 en 81 casos (7 no valorables). Los hfms presentaron un elevado indice de proliferaci\u00f3n que correspondi\u00f3 a grados iii \u00f3 iv (67 % hfms) de mlb-1. La actividad proliferativa grados iii \u00f3 iv contrastada con la posibilidad de desarrollar recidivas, met\u00e1stasis y muertes por tumor result\u00f3 tener significaci\u00f3n estad\u00edstica. La determinaci\u00f3n del oncogen p-53 revel\u00f3 que 37 tumores (50%) mostraron positividad nuclear. la prueba de chi-cuadrado de pearson no revel\u00f3 valor estad\u00edsticamente significativa en la expresi\u00f3n de p53 con la aparici\u00f3n de recedivas, met\u00e1stasis ni muertes por tumor. Se concluye observando que el clohfm es una neoplasia maligna de los tejidos blandos que afecta a individuos entre la 6ta-8va decadas de la arda. La localizaci\u00f3n preferente del hfm son las extremidades (59%). el tipo histopatol\u00f3gico m\u00e1s frecuente es el hfm patr\u00f3n pleom\u00f3rfico (72%) el hfm es un sarcoma de alto indice de proliferaci\u00f3n como lo prueba el hecho de que el 67 % de los casos estudiados con mib 1 corresponden a grados altos de proliferaci\u00f3n (grados iii \u00f3 iv). La expresi\u00f3n del oncogen p53 no tiene valor estadisticamente significativo en relaci\u00f3n al comportamiento biol\u00f3gico y pronostico del hfm y el grado de proliferaci\u00f3n medido con mib-1 si tiene relaci\u00f3n directa con el pron\u00f3stico. Ya que el 75, 86% de recidivas 56,25 % de las met\u00e1stasis y 60,71 de las muertes por tumor se presentaron en neoplasias con grados de proliferaci\u00f3n iii \u00f3 iv<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Histiocitoma fibroso maligno de los tejidos blandos, estudio clinico patologico de 85 casos con especial referencia al valor pronostico del indice de proliferacion celular y de la expresion del oncogen p53<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Histiocitoma fibroso maligno de los tejidos blandos, estudio clinico patologico de 85 casos con especial referencia al valor pronostico del indice de proliferacion celular y de la expresion del oncogen p53 <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Duran Hernandez M. Cristina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 A coru\u00f1a<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Varela Duran<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Rivera pomar <\/li>\n<li>eugenio Perez becerra (vocal)<\/li>\n<li>Luis Miguel Anton aparicio (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Duran Hernandez M. Cristina En este trabajo de investigaci\u00f3n se estudian 85 casos de histiocitomas fibrosos malignos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[18576],"tags":[85749,21596,13350,21341,52649],"class_list":["post-30538","post","type-post","status-publish","format-standard","hentry","category-a-coruna","tag-duran-hernandez-m-cristina","tag-eugenio-perez-becerra","tag-jose-maria-rivera-pomar","tag-juan-varela-duran","tag-luis-miguel-anton-aparicio"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30538","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=30538"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30538\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=30538"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=30538"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=30538"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}