{"id":30558,"date":"2004-07-06T00:00:00","date_gmt":"2004-07-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-las-proteinas-rgs-en-el-snc-del-raton-plasticidad-en-respuesta-a-la-administracion-de-opioides\/"},"modified":"2004-07-06T00:00:00","modified_gmt":"2004-07-06T00:00:00","slug":"caracterizacion-de-las-proteinas-rgs-en-el-snc-del-raton-plasticidad-en-respuesta-a-la-administracion-de-opioides","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-las-proteinas-rgs-en-el-snc-del-raton-plasticidad-en-respuesta-a-la-administracion-de-opioides\/","title":{"rendered":"Caracterizaci\u00f3n de las prot\u00e9inas rgs en el snc del rat\u00f3n. plasticidad en respuesta a la administraci\u00f3n de opioides."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  L\u00f3pez Fando Santaf\u00e9 Almudena <\/strong><\/h2>\n<p>Las prote\u00ednas rgs o reguladoras de la se\u00f1alizaci\u00f3n mediante prote\u00ednas g (regulators of g-protein signaling)participan en la modulaci\u00f3n de los efectos opioides.El an\u00e1lisis mediante rt-pcr (transcripci\u00f3n reversa-reacci\u00f3n en cadena de la polimerasa)ha evidenciado una distribuci\u00f3n generalizada del mensajero de las prote\u00ednas rgs en el snc del rat\u00f3n .Los estudios realizados mediante la generaci\u00f3n de animales knockdown frente a determinadas rgs as\u00ed como los ensayos de uni\u00f3n de gtpys 35 y de hidr\u00f3lisis de gtpyp32 nos han permitido determinar el mecanismo molecular de actuaci\u00f3n de algunas subfamilias de rgs. En este sentido , la subfamilia c\/r7 de rgs (formada por las rgs6,rgs7,rgs9 y rgs11)as\u00ed como la subunidad gb7 a la que se unen espec\u00edficamente todos los miembros , de esta subfamilia parecen tener un mecanismo similar.\u00e9Stas prote\u00ednas participan en el secuestro de subunidades ga favoreciendo el empobrecimiento de prote\u00ednas g en el entorno del receptor susceptibles de ser reguladas por el mismo y originario la aparici\u00f3n de tolerancia aguda.Por otro lado. La disminuci\u00f3n en la expresi\u00f3n (animales knockosow)de las rgsz1 y rgs4 prosuce un incremento en la anlgesia morf\u00ednica sin que se modifique la tolerancia aguda al alcaloide.El mecanismo molecular de actuaci\u00f3n de la rgsz1 se deriva de su capacidad para unir subunidades ga en estado gtp , impidiendo que una fracci\u00f3n de las gaz-gtp activadas por opioides lleguen a unirse al efectro.Los resultados obtenidos indican una regulaci\u00f3n preferencial d la subunidades gai\/o sobre las gaz por la rgs4.Como estudio complementario se ha analizado la plasticidad en la expresi\u00f3n del mrna de las rgs frente a diferentes tratamientos (agudos y cr\u00f3nicos )con morfina.La morfina , a dosis capaces de producir tolerancia aguda en ratones, induce variaciones en la expresi\u00f3n del mrna de las rgs c\/r7 durante las dos primeras horas post-inyecci\u00f3n .El tratamiento cr\u00f3nico con morfina promueve cambi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de las prot\u00e9inas rgs en el snc del rat\u00f3n. plasticidad en respuesta a la administraci\u00f3n de opioides.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de las prot\u00e9inas rgs en el snc del rat\u00f3n. plasticidad en respuesta a la administraci\u00f3n de opioides. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  L\u00f3pez Fando Santaf\u00e9 Almudena <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pilar S\u00e1nchez Blazquez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: \u00e1ngel Villar del fresno <\/li>\n<li>adela Sanchez garcia (vocal)<\/li>\n<li>olga Valverde granados (vocal)<\/li>\n<li>nazario Rubio arazuri (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de L\u00f3pez Fando Santaf\u00e9 Almudena Las prote\u00ednas rgs o reguladoras de la se\u00f1alizaci\u00f3n mediante prote\u00ednas g (regulators of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[1976,4663,85797,85798,66981,7569],"class_list":["post-30558","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-adela-sanchez-garcia","tag-angel-villar-del-fresno","tag-lopez-fando-santafe-almudena","tag-nazario-rubio-arazuri","tag-olga-valverde-granados","tag-pilar-sanchez-blazquez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30558","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=30558"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30558\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=30558"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=30558"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=30558"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}