{"id":30705,"date":"2004-11-06T00:00:00","date_gmt":"2004-11-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/infecciones-relacionadas-con-biofilms-estudio-prospectivo-del-diagnostico-y-tratamiento-conservador-de-la-bacteriemia-relacionada-con-cateter-venoso-central-con-reservorio-subcutaneo\/"},"modified":"2004-11-06T00:00:00","modified_gmt":"2004-11-06T00:00:00","slug":"infecciones-relacionadas-con-biofilms-estudio-prospectivo-del-diagnostico-y-tratamiento-conservador-de-la-bacteriemia-relacionada-con-cateter-venoso-central-con-reservorio-subcutaneo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/infecciones-relacionadas-con-biofilms-estudio-prospectivo-del-diagnostico-y-tratamiento-conservador-de-la-bacteriemia-relacionada-con-cateter-venoso-central-con-reservorio-subcutaneo\/","title":{"rendered":"Infecciones relacionadas con biofilms. estudio prospectivo del diagn\u00f3stico y tratamiento conservador de la bacteriemia relacionada con cat\u00e9ter venoso central con reservorio subcut\u00e1neo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Luis Del Pozo Le\u00f3n <\/strong><\/h2>\n<p>Los cat\u00e9teres venosos centrales con reservorio subcut\u00e1neo (cvcr) son herramientas imprescindibles para el manejo de los pacientes oncol\u00f3gicos. La infecci\u00f3n es complicaci\u00f3n m\u00e1s grave asociada a su uso y genera una considerable morbi-mortalidad adem\u00e1s de un tremendo coste hospitalario. La formaci\u00f3n de biofilms bacterianos en el interior de estos dispositivos es la causa del fracaso de los tratamientos antibi\u00f3ticos convencionales.  en este trabajo hemos estudiado el papel del diagn\u00f3stico y tratamiento conservador mediante sellado antibi\u00f3tico (sa) de la bacteriemia relacionada con cvcr (brcvcr). Para ello, hemos desarrollado un modelo in vitro de colonizaci\u00f3n de un reservorio subcut\u00e1neo que nos ha permitido optimizar las pautas de sellado antibi\u00f3tico a utilizar in vivo. El contacto prolongado de una concentraci\u00f3n elevada de un antibi\u00f3ticdo con un biofilm estafiloc\u00f3cico, es capaz de esterilizar el biomaterial en un modelo in vitro. La eficacia del antibi\u00f3tico se ve afectada por su concentraci\u00f3n y por la longevidad del biofilm. A mayor concentraci\u00f3n del antibi\u00f3tico mayor eficacia, y a mayor longevidad del biofilm mayor resistencia a la acci\u00f3n antibi\u00f3tica. los antibi\u00f3ticos que se han mostrado m\u00e1s eficaces han sido: rifampicina, teicoplanina, vancomicina, levofloxacino, quinupristina-dalfopristina, linezolid y cloxacilina. Clindamicina, cloranfenicol, claritromicina y fosfomicina, se han mostrado poco eficaces frente a los biofilms estudiados.  en base a los resultados obtenidos, analizamos la eficacia de distintas pautas de sa en el tratamiento conservador de 70 episodios de brcvcr, en t\u00e9rminos de mejor\u00eda cl\u00ednica del paciente, mantenimiento del dispositivo, aumento de su permanencia y posibilidad de tratamiento ambulatorio.  el tratamiento mediante sa, permiti\u00f3 recuperar el dispositivo en un 90,3% de los casos.  por \u00faltimo nos propusimos avaluar las posibilidades diagn\u00f3sticas de los sistemas automatizados de det<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Infecciones relacionadas con biofilms. estudio prospectivo del diagn\u00f3stico y tratamiento conservador de la bacteriemia relacionada con cat\u00e9ter venoso central con reservorio subcut\u00e1neo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Infecciones relacionadas con biofilms. estudio prospectivo del diagn\u00f3stico y tratamiento conservador de la bacteriemia relacionada con cat\u00e9ter venoso central con reservorio subcut\u00e1neo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Luis Del Pozo Le\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Leiva Le\u00f3n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: guillem Prats pastor <\/li>\n<li> Azanza perea Jos\u00e9 ram\u00f3n (vocal)<\/li>\n<li>i\u00f1igo Lasa uzcudun (vocal)<\/li>\n<li>Jes\u00fas Fort\u00fan abete (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Luis Del Pozo Le\u00f3n Los cat\u00e9teres venosos centrales con reservorio subcut\u00e1neo (cvcr) son herramientas imprescindibles para [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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