{"id":30736,"date":"2018-03-09T09:24:29","date_gmt":"2018-03-09T09:24:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-interleucina-6-secretada-por-las-celulas-de-kupffer-es-la-responsable-de-la-iniciacion-del-proceso-de-regeneracion-hepatica-post-hepatectoma%c2%ada-parcial-en-un-modelo-animal-experimental\/"},"modified":"2018-03-09T09:24:29","modified_gmt":"2018-03-09T09:24:29","slug":"la-interleucina-6-secretada-por-las-celulas-de-kupffer-es-la-responsable-de-la-iniciacion-del-proceso-de-regeneracion-hepatica-post-hepatectoma%c2%ada-parcial-en-un-modelo-animal-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-interleucina-6-secretada-por-las-celulas-de-kupffer-es-la-responsable-de-la-iniciacion-del-proceso-de-regeneracion-hepatica-post-hepatectoma%c2%ada-parcial-en-un-modelo-animal-experimental\/","title":{"rendered":"La interleucina-6 secretada por las c\u00e9lulas de kupffer es la responsable de la iniciaci\u00f3n del proceso de regeneraci\u00f3n hep\u00e1tica post-hepatectom\u00edaparcial en un modelo animal experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Xavier Aldeguer Mante <\/strong><\/h2>\n<p>Se requiere de la interleucina 6 (il-6) para la regeneraci\u00f3n normal del h\u00edgado pero la fuente espec\u00edfica de este factor de crecimiento permanece desconocida.  en este estudio se ha investigado si la se\u00f1al se origina del macr\u00f3fago hep\u00e1tico, la c\u00e9lula de kupffer. Para realizar este estudio, se ha utilizado un modelo animal de transplante de m\u00e9dula \u00f3sea en ratones. Espec\u00edficamente, se han reemplazado las c\u00e9lulas derivadas de lam \u00e9dula \u00f3sea del receptor, inclu\u00eddas, por tanto, las c\u00e9lulas de kupffer, por las del donante con sus correspondientes caracter\u00edsticas genot\u00edpicas.  los receptores, en este caso, eran ratones deficientes gen\u00e9ticamente en su capacidad de producci\u00f3n de il-6, ratones knockout il-6 (ko il-6), i en los que hab\u00eda quedado plenamente demostrado en la literatura que eran incapaces de tener regeneraci\u00f3n hep\u00e1tica normal. Estos ratones se irradiaban con una dosis letal conocida de 1000 rads y se rescataban con el transplante de m\u00e9dula \u00f3sea de ratones de la misma cepa pero gen\u00e9ticamente normales (il -6 +\/+), es decir con capacidad de producci\u00f3n de il-6.  de esta menera, se pretende la creaci\u00f3n de un animal quimera, en el que la \u00fanica fuente de il-6 proviniera de sus c\u00e9lulas derivadas de la m\u00e9dula \u00f3sea. Se tranplantaban un total de 10 7 c\u00e9lulas.  inversamente, se hac\u00eda el mismo procedimiento con el transplante de c\u00e9lulas de animales ko a animales genot\u00edpicamente normales. El \u00e9xito del injerto, se demostraba inicialmente con la supervivencia del animal m\u00e1s all\u00e1 de 6 semanas. La comprobaci\u00f3n experimental de este injerto se hac\u00eda inicialmente con la demostraci\u00f3n del fragmento sry del cromosoma y en los h\u00edgados de animales hembra que se hab\u00edan transplantado c\u00e9lulas de animales macho. posteriormente, se objetivaba la expresi\u00f3n in situ de il-6 por parte de las c\u00e9lulas de kupffer en los animales receptores ko y la producci\u00f3n de il-6 por parte de los esplenocitos de estos animales despu\u00e9s de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La interleucina-6 secretada por las c\u00e9lulas de kupffer es la responsable de la iniciaci\u00f3n del proceso de regeneraci\u00f3n hep\u00e1tica post-hepatectom\u00edaparcial en un modelo animal experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La interleucina-6 secretada por las c\u00e9lulas de kupffer es la responsable de la iniciaci\u00f3n del proceso de regeneraci\u00f3n hep\u00e1tica post-hepatectom\u00edaparcial en un modelo animal experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Xavier Aldeguer Mante <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Gassull Dur\u00f3 Miquel Angel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: august Corominas vilardell <\/li>\n<li>ram\u00f3n Planas vil\u00ed\u00a0 (vocal)<\/li>\n<li>antoni Rimola castell\u00ed\u00a0 (vocal)<\/li>\n<li>esther Fern\u00e1ndez gimeno (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Xavier Aldeguer Mante Se requiere de la interleucina 6 (il-6) para la regeneraci\u00f3n normal del h\u00edgado pero 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