{"id":30784,"date":"2018-03-09T09:24:33","date_gmt":"2018-03-09T09:24:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/organizacion-estructural-y-capacidades-de-union-de-las-espermadhesinas-psp-i-y-psp-ii\/"},"modified":"2018-03-09T09:24:33","modified_gmt":"2018-03-09T09:24:33","slug":"organizacion-estructural-y-capacidades-de-union-de-las-espermadhesinas-psp-i-y-psp-ii","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/organizacion-estructural-y-capacidades-de-union-de-las-espermadhesinas-psp-i-y-psp-ii\/","title":{"rendered":"Organizaci\u00f3n estructural y capacidades de union de las espermadhesinas psp-i y psp-ii"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Campanero Rhodes M. Asunci\u00f3n <\/strong><\/h2>\n<p>Las epsermadhesinas son una familia de prote\u00ednas presentes en el plasma seminal de diversas especies de mam\u00edferos que recubren la superficie de los espermatozoides en la eyaculaci\u00f3n. Son prote\u00ednas multivalentes, con capacidad de unir diversos tipos de ligandos aunque a\u00fan no se conoce su funci\u00f3n, se cree que est\u00e1n implicads en m\u00e1s de una etapa del proceso de la fecundaci\u00f3n.  psp-i y psp-ii son las espermadhesinas porcinas m\u00e1s abundantes que, en el plasma seminal, se hallan formando un heterod\u00edmero no convalente cuyas caracter\u00edsticas estructurales se han estudiado extensivamente. Sin embargo, se sabe muy poco acerca de las subunidades psp-i y psp-ii aisladas, existiendo, adem\u00e1s, controversia en cuanto a sus capacidades de uni\u00f3n a ligandos.  en esta tesis doctroal se ha llevado a cabo un estudio de la organizaci\u00f3n estructural, estabilidad y estado de agregaci\u00f3n e psp-i y psp-ii y se han delimitado sus capacidades de uni\u00f3n a ligandos as\u00ed como la interdependencia de las distintas interacciones. As\u00ed mismo, se ha explorado en ambas prote\u00ednas un posible sitio de uni\u00f3n  a inhibidores de proteasas y la zona de uni\u00f3n a heparina en psp-ii y en pdc-109, la prote\u00edna mayoritaria del plasma seminal bovino compatibles con la inter-relaci\u00f3n observada entre las distintas capacidades de uni\u00f3n a ligandos de estas prote\u00ednas.  por \u00faltimo, se ha estudiado el efecto del zn2+, un cation muy abundante en plasma seminal, sobre la organizaci\u00f3n estructural y reconocimiento de ligandos del heterod\u00edmero y de ambas subunidades, demostr\u00e1ndose un papel regulador de dicho cati\u00f3n sobre el estado de agregaci\u00f3n y capacidad de uni\u00f3n a heparina de psp-i. Adem\u00e1s, aunque no se han encontrado ligandos para el heterod\u00edmero psp-i\/psp-ii, se ha comprobado que en determinadas condiciones fisiol\u00f3gicas (baja concentraci\u00f3n de prote\u00ednas y ph \u00e1cido o presencia de zn2+) se produce su disociaci\u00f3n, permitiendo de este modo la funcionalidad de las capac<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Organizaci\u00f3n estructural y capacidades de union de las espermadhesinas psp-i y psp-ii<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Organizaci\u00f3n estructural y capacidades de union de las espermadhesinas psp-i y psp-ii <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Campanero Rhodes M. Asunci\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Dolores Solis S\u00e1nchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Lozano fern\u00e1ndez <\/li>\n<li>margarita Menendez fernandez (vocal)<\/li>\n<li>Juan  Jos\u00e9 Calvete chornet (vocal)<\/li>\n<li>Juan  Mar\u00eda Vazquez rojas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Campanero Rhodes M. Asunci\u00f3n Las epsermadhesinas son una familia de prote\u00ednas presentes en el plasma seminal de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[86292,86293,56559,25098,54522,22756],"class_list":["post-30784","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-campanero-rhodes-m-asuncion","tag-dolores-solis-sanchez","tag-juan-jose-calvete-chornet","tag-juan-maria-vazquez-rojas","tag-margarita-menendez-fernandez","tag-rafael-lozano-fernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30784","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=30784"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30784\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=30784"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=30784"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=30784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}