{"id":30807,"date":"2018-03-09T09:24:35","date_gmt":"2018-03-09T09:24:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/relevancia-del-acetaldehido-la-hipoxia-y-la-mitocondria-en-la-hepatopatia-alcoholica\/"},"modified":"2018-03-09T09:24:35","modified_gmt":"2018-03-09T09:24:35","slug":"relevancia-del-acetaldehido-la-hipoxia-y-la-mitocondria-en-la-hepatopatia-alcoholica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/relevancia-del-acetaldehido-la-hipoxia-y-la-mitocondria-en-la-hepatopatia-alcoholica\/","title":{"rendered":"Relevancia del acetaldehido, la hipoxia y la mitocondria en la hepatopatia alcoholica."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  LLuis Duquez Jos\u00e9 M. <\/strong><\/h2>\n<p>La hepatopat\u00eda alcoh\u00f3lica es un proceso multifactorial y entre los mecanismos implicados en su desarrollo cabe destacar la produci\u00f3n de acetaldeh\u00eddo, la disminuci\u00f3n selectiva de los niveles de glutation (gsh)mitocondrial y la hipoxia en la zona centrilobular del h\u00edgado consecuencia del metabolismo oxidativo del etanol.Una de las caracteristicas predominantes del da\u00f1o hep\u00e1tico inducido por el alcohol en el h\u00edgado, son las alteraciones morfolog\u00edcas y funcionales que se observan en las mitocondrias.  por tanto, uno de los objetivos de la presente tesis fue evaluar.  1.El papel del acetaldeh\u00eddo en la regulaci\u00f3n y transporte de glutation a la mitocondria, as\u00ed como en la composici\u00f3n lip\u00eddica y las propiedades fisicas de la membrana mitocondrial.  el primer trabajo aporta informaci\u00f3n sobre el mecanismo en la disminuci\u00f3n selectiva de glutation mitocondrial, debido al consumo cr\u00f3nico de etanol.El acetaldeh\u00eddo, el primer metabolito del metabolismo oxidativo del etanol,redujo la afinidad (aumento la km)delos dos componentes implicados en el transportes de gsh a la mitocondria y esto fue acompa\u00f1ado de una disminuci\u00f3n de los nieveles de glutaci\u00f3n mitocondrial (mgsh).Esta disfunci\u00f3n en eltrasporte de mgsh se relacion\u00f3 con un aumento en la viscosidad de la emnbrana mitocondrial consecuencia de un aumento en los niveles de colesterol en la mitocondria.Por otro lado, el acetaldeh\u00eddo indujo la expresi\u00f3n de los factores gadd153, marcador de estr\u00e9s en el ret\u00edculo endoplasm\u00e1tico, y srebp-1, implicado en la activaci\u00f3n de enzimas responsables de la s\u00edntesis de colesterol.Por \u00faltimo, el descenso en los niveles de mgsh, sensibiliz\u00f3 las c\u00e9lulas hepg2 a los efectos citot\u00f3xico del tnf-a.  hay evidencias que muestran un deposito de colesterol enla membrana mitocondrial, lo que conlleva una disminuci\u00f3n de la fluidez de la bicapa lip\u00eddaca.Dada la implicaci\u00f3n de la apertura del poro mitocondrial a citoquinas(tnf-a fas) en la hep<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Relevancia del acetaldehido, la hipoxia y la mitocondria en la hepatopatia alcoholica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Relevancia del acetaldehido, la hipoxia y la mitocondria en la hepatopatia alcoholica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  LLuis Duquez Jos\u00e9 M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>checa Torres Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joan Serratosa seda <\/li>\n<li>joan Gimenez rovira (vocal)<\/li>\n<li>albert Pol sorolla (vocal)<\/li>\n<li>julia Panes diaz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de LLuis Duquez Jos\u00e9 M. La hepatopat\u00eda alcoh\u00f3lica es un proceso multifactorial y entre los mecanismos implicados en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,849],"tags":[86352,86349,86351,86350,86036,86348],"class_list":["post-30807","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-biologia-celular","tag-albert-pol-sorolla","tag-checa-torres-fernandez","tag-joan-gimenez-rovira","tag-joan-serratosa-seda","tag-julia-panes-diaz","tag-lluis-duquez-jose-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30807","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=30807"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30807\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=30807"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=30807"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=30807"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}