{"id":30836,"date":"2018-03-09T09:24:38","date_gmt":"2018-03-09T09:24:38","guid":{"rendered":""},"modified":"2018-03-09T09:24:38","modified_gmt":"2018-03-09T09:24:38","slug":"analisis-de-la-influencia-del-polimorfismo-4g-5g-sobre-la-expresion-endotelial-de-pai-1-en-respuesta-a-esta%c2%admulos-aterogenicos-y-al-tratamiento-antihipertensivo-e-hipolipemiante-valoracion-del-r","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/analisis-de-la-influencia-del-polimorfismo-4g-5g-sobre-la-expresion-endotelial-de-pai-1-en-respuesta-a-esta%c2%admulos-aterogenicos-y-al-tratamiento-antihipertensivo-e-hipolipemiante-valoracion-del-r\/","title":{"rendered":"An\u00e1lisis de la influencia del polimorfismo 4g\/5g sobre la expresi\u00f3n endotelial de pai-1 en respuesta a est\u00edmulos aterog\u00e9nicos y al tratamiento antihipertensivo e hipolipemiante. valoraci\u00f3n del riesgo vascular ateroscler\u00f3tico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Roncal Mancho <\/strong><\/h2>\n<p>Se ha examinado la influencia del polimorfismo 4g\/5g sobre la expresi\u00f3n endotelial de pai-1 en respuesta a angiotensina ii (ang ii), interleucina-1 (il-1) y lipoprote\u00ednas de baja densidad (ldl) en presencia y ausencia de f\u00e1rmacos antiateroscler\u00f3ticos. Asimismo se han determinado los niveles antig\u00e9nicos de pai-1 en relaci\u00f3n al polimorfismo 4g\/5g en sujetos aparentemente sanos (n=170). Se estimularon c\u00e9lulas endoteliales de la vena de cord\u00f3n umbilical humano (huvec) con ang ii (10-8 m), il-1 (500u\/ml) y ldl (100 ug\/ml) en presencia o ausencia de losartan (0,01-0,05um), pravastatina (1-5um) y gemfibrozilo (50-500um) respectivamente durante 24 horas . El mrna de pai-1 se determin\u00f3 en extractos celulares y la secreci\u00f3n y actividad en sobrenadantes y matriz extracelular (mec). La ang ii aument\u00f3 la expresi\u00f3n, actividad y secreci\u00f3n de pai-1 en huvec 4g\/4g significativamente (p menor 0,05) respecto a las huvec 4g\/5g y 5g\/5g. Mediante micrsocop\u00eda confocal se observ\u00f3 que la mayor\u00eda de la prote\u00edna se localizaba a nivel de la mec. este aumento de expresi\u00f3n y secreci\u00f3n fue inhibido en presencia de losartan (p menor 0,05) indicando un efecto mediado por los receptores at1. Tanto ll-1 como ldl oxidadas aumentaron la expresi\u00f3n de pai-1 en huvec 4g\/4g en comparaci\u00f3n con los controles. El pretratamiento con 5um de pravastatina y 50 um de gemfibrozilo redujo este efecto, indicando una acci\u00f3n antiinflamatoria de estos f\u00e1rmacos. Subgrupos de pacientes hipertensos y obesos con genotipo 4g\/4g presentaron niveles significativamente aumentados de pai-1 (p menor 0,05) (35,3 +- 24,2  vs  25,6 +- 12,1 ng\/ml)  (43,5 +- 23,2  vs  24,9 +- 9,5ng\/ml), respecto a los hipertensos y obesos 5g\/5g. El polimorfismo 4g\/5g de pai-1 determina una respuesta endotelial genotipo dependiente a ang ii, ll-1 y ldl oxidadas siendo su modulaci\u00f3n con losartam, pravastatina y gemfibrozilo dependiente de dicho genotipo. El an\u00e1lisis de polimorfismo 4g\/5g del pai-1 podr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis de la influencia del polimorfismo 4g\/5g sobre la expresi\u00f3n endotelial de pai-1 en respuesta a est\u00edmulos aterog\u00e9nicos y al tratamiento antihipertensivo e hipolipemiante. valoraci\u00f3n del riesgo vascular ateroscler\u00f3tico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de la influencia del polimorfismo 4g\/5g sobre la expresi\u00f3n endotelial de pai-1 en respuesta a est\u00edmulos aterog\u00e9nicos y al tratamiento antihipertensivo e hipolipemiante. valoraci\u00f3n del riesgo vascular ateroscler\u00f3tico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Roncal Mancho <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Paramo Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joaquin del Rio zambrana <\/li>\n<li>amparo Estell\u00e9s cort\u00e9s (vocal)<\/li>\n<li>eduardo Angl\u00e9s cano (vocal)<\/li>\n<li>justo Aznar lucea (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Roncal Mancho Se ha examinado la influencia del polimorfismo 4g\/5g sobre la expresi\u00f3n endotelial de pai-1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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