{"id":30846,"date":"2018-03-09T09:24:38","date_gmt":"2018-03-09T09:24:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-de-nuevos-inhibidores-de-acetilcolinesterasa-de-interes-potencial-en-relacion-con-la-enfermedad-de-alzheimer\/"},"modified":"2018-03-09T09:24:38","modified_gmt":"2018-03-09T09:24:38","slug":"sintesis-de-nuevos-inhibidores-de-acetilcolinesterasa-de-interes-potencial-en-relacion-con-la-enfermedad-de-alzheimer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-farmaceutica\/sintesis-de-nuevos-inhibidores-de-acetilcolinesterasa-de-interes-potencial-en-relacion-con-la-enfermedad-de-alzheimer\/","title":{"rendered":"Sintesis de nuevos inhibidores de acetilcolinesterasa de inter\u00e9s potencial en relaci\u00f3n con la enfermedad de alzheimer"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena G\u00f3mez Castillo <\/strong><\/h2>\n<p>En la presente tesis doctoral se han sintetizado por primera vez dos ejemplos de huprinas (h\u00edbridos huperzina a-tacrina: 9-alquil-12-amino-6,7,10,11-tetrahidro-7,11-metanoclicloocta[b]quinolina) que presentan el anillo de aminoquinolina y el doble enlace c=c endoc\u00edclico en una disposici\u00f3n relativa sin (sin huprinas), operando en condiciones fuertemente b\u00e1sicas, a diferencia de la reacci\u00f3n de friedl\u00ed\u00a4nder, utilizada normalmente para la obtenci\u00f3n de las anti huprinas, que tiene lugar en condiciones \u00e1cidas. Las sin huprinas rac\u00e9micas se han isomerizado a las correspondientes anti huprinas en medio \u00e1cido. Asimismo, se han isomerizado las sin huprinas en forma enantioenriquecida, obtenidas mediante resoluci\u00f3n cromatogr\u00e1fica por mplc quiral, a las correspondientes anti huprinas enantioenriquecidas. estos resultados, sugieren que en la reacci\u00f3n friedl\u00ed\u00a4nder se forma inicialmente una mezcla de sin y anti huprinas, isomeriz\u00e1ndose posteriormente las sin huprinas a las anti huprinas en las condiciones \u00e1cidas de la reacci\u00f3n. si bien la sin-huprinas muestran una interesante activida inhibidora de la ache, son claramente menos activas que las correspondientes anti huprinas.  por otra parte, se han preparado a escala multigrano los dos diastereois\u00f3meros del 3-metil-6-metanosulfonamido-2-oxa-1-adamantilo en foram diastereopura y se ha puesto a punto una metodolog\u00eda para su fragmentaci\u00f3n eficiente a las correspondientes enonas bic\u00edclicas (9-metanosulfonamido-7-metilbiciclo[3.3.1]non-6-en-3-ona]. se han preparado las correspondientes huprinas funcionalizadas con un grupo metanosulfonamido en la posici\u00f3n 13. El tratamiento de \u00e9stas con ppa en caliente ha permitido su hidr\u00f3lisis a las aminas deseadas, cuya conversi\u00f3n en las correspondientes 13-formamido- y 13-acetamido-huprinas, se llev\u00f3 a cabo a trav\u00e9s de procedimientos est\u00e1ndar. Si bien algunos compuestos de esta nueva familia de huprinas funcionalizadas en la posici\u00f3n 13 con un gr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis de nuevos inhibidores de acetilcolinesterasa de inter\u00e9s potencial en relaci\u00f3n con la enfermedad de alzheimer<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis de nuevos inhibidores de acetilcolinesterasa de inter\u00e9s potencial en relaci\u00f3n con la enfermedad de alzheimer <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena G\u00f3mez Castillo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pelayo Camps Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jordi Marquet cortes <\/li>\n<li>Miguel \u00e1ngel Yus astiz (vocal)<\/li>\n<li>Jos\u00e9 Fuentes mota (vocal)<\/li>\n<li>Fernando Albericio palomera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena G\u00f3mez Castillo En la presente tesis doctoral se han sintetizado por primera vez dos ejemplos de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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