{"id":30862,"date":"2018-03-09T09:24:40","date_gmt":"2018-03-09T09:24:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-de-azaazucares-con-estructuras-pirrolida%c2%adnicas-piperida%c2%adnicas-y-azepanicas-a-partir-de-epoxiamidas\/"},"modified":"2018-03-09T09:24:40","modified_gmt":"2018-03-09T09:24:40","slug":"sa%c2%adntesis-de-azaazucares-con-estructuras-pirrolida%c2%adnicas-piperida%c2%adnicas-y-azepanicas-a-partir-de-epoxiamidas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/malaga\/sa%c2%adntesis-de-azaazucares-con-estructuras-pirrolida%c2%adnicas-piperida%c2%adnicas-y-azepanicas-a-partir-de-epoxiamidas\/","title":{"rendered":"S\u00edntesis de azaaz\u00facares con estructuras pirrolid\u00ednicas, piperid\u00ednicas y azep\u00e1nicas a partir de epoxiamidas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Assiego De Larriva M. Carmen <\/strong><\/h2>\n<p>La presente tesis doctoral realiza un profundo estudio de las aplicaciones de las epoxiamidas derivadas de monosac\u00e1ridos en la s\u00edntesis de los denominados aza-az\u00facares, compuestos anal\u00f3gicos de lso carbohidratos donde se sustituye el ox\u00edgeno presente en el anillo por un nitr\u00f3geno. La preparaci\u00f3n inicial de las epoxiamidas se realiz\u00f3 de forma muy eficiente, en t\u00e9rminos de rendimiento qu\u00edmico y estereoselectividad, a partir de furanosas por reacci\u00f3n con iluros de azufre estabilizados con un grupo amida. Las epoxiamidas resultantes fueron sometidas a extensivos estudios de aperturas nucleof\u00edlicas, protecciones selectivas, oxidaci\u00f3n y activaci\u00f3n de grupos hidroxilos, de manera que se puso preparar una amplia variedad de derivados de aza-az\u00facares con estructuras tipo pirrolid\u00ednicas, piperid\u00ednicas y azep\u00e1nicas, tanto de la serie d como de la serie l. La tesis se completa con un extenso estudio espectrosc\u00f3pico de los productos preparados y deja las puertas abiertas a futuras investigaciones dirigidas hacia la evaluaci\u00f3n biol\u00f3gica de este tipo de compuestos, representando interesantes y potenciales agentes inhibidores de glicosidasas, as\u00ed como se establecen las bases para el desarrollo de compuestos de mayor complejidad estructural y con un mayor potencial biom\u00e9dico, como son las c-glicoprote\u00ednas. en resumen, la presente tesis describe una nueva metodolog\u00eda sint\u00e9tica de mim\u00e9ticos de carbohidratos tipo aza-az\u00facares desde una nueva metodolog\u00eda sint\u00e9tica de mim\u00e9ticos de carbohidratos tipo aza-az\u00facares desde productos comunes tipo epoxiamidas derivadas de monosac\u00e1ridos. La qu\u00edmica desarrollada desde estas epoxi-amidas ha permitido la preparaci\u00f3n controlada y eficiente de una amplia gama de productos de inter\u00e9s biol\u00f3gico cuya evaluaci\u00f3n y derivaci\u00f3n hacia otros an\u00e1logos formar\u00e1 parte de futuras acciones de investigaci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis de azaaz\u00facares con estructuras pirrolid\u00ednicas, piperid\u00ednicas y azep\u00e1nicas a partir de epoxiamidas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis de azaaz\u00facares con estructuras pirrolid\u00ednicas, piperid\u00ednicas y azep\u00e1nicas a partir de epoxiamidas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Assiego De Larriva M. Carmen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Pino Gonz\u00e1lez M. Soledad<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: sergio Castillon miranda <\/li>\n<li>isidoro Izquierdo cubero (vocal)<\/li>\n<li>pierre Vogel (vocal)<\/li>\n<li>inmaculada Robina ramirez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Assiego De Larriva M. Carmen La presente tesis doctoral realiza un profundo estudio de las aplicaciones de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[7834],"tags":[86462,43722,3851,86464,86463,32735],"class_list":["post-30862","post","type-post","status-publish","format-standard","hentry","category-malaga","tag-assiego-de-larriva-m-carmen","tag-inmaculada-robina-ramirez","tag-isidoro-izquierdo-cubero","tag-pierre-vogel","tag-pino-gonzalez-m-soledad","tag-sergio-castillon-miranda"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30862","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=30862"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30862\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=30862"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=30862"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=30862"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}