{"id":30880,"date":"2018-03-09T09:24:41","date_gmt":"2018-03-09T09:24:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/virus-modificados-como-agentes-terapeuticos-aplicaciones-en-cancer-de-mama-y-otros-modelos\/"},"modified":"2018-03-09T09:24:41","modified_gmt":"2018-03-09T09:24:41","slug":"virus-modificados-como-agentes-terapeuticos-aplicaciones-en-cancer-de-mama-y-otros-modelos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/virus-modificados-como-agentes-terapeuticos-aplicaciones-en-cancer-de-mama-y-otros-modelos\/","title":{"rendered":"Virus modificados como agentes terape\u00faticos: aplicaciones en c\u00e1ncer de mama y otros modelos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Parada Cobo <\/strong><\/h2>\n<p>El uso de virus modificados como agentes terap\u00e9uticos en pacientes de c\u00e1ncer es actualmente un campo en desarrollo. Es la llamada terapia g\u00e9nica de c\u00e1ncer. Para intentar mejorar las potencialidades de estas terapias, hemos desarrollado dos tipos de estrategias, el uso de adenovirus replicativos condicionales y la potenciaci\u00f3n de las llamadas terapias suicidas, para lo cual hemos generado dos tipos de vectores, adenovirales y retrovirales. los estudios que presentamos demuestran la capacidad de adenovirus adl118 para eliminar met\u00e1stasis en un modelo de c\u00e1ncer de mama in vivo, y la capacidad de la prote\u00edna e1a, como agente inductor del ciclo celular, para potenciar el efecto oncol\u00edtico del sistema suicida hsv1-tk\/gcv. Adem\u00e1s hemos tratado de profundizar en la biolog\u00eda delos adenovirus, estudiando las rutas de transducci\u00f3n de se\u00f1ales activadas en respuesta a la infecci\u00f3n, as\u00ed como la capacidad de e1a 12s de inducir replicaci\u00f3n viral en adenovirus e1 deficientes.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Virus modificados como agentes terape\u00faticos: aplicaciones en c\u00e1ncer de mama y otros modelos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Virus modificados como agentes terape\u00faticos: aplicaciones en c\u00e1ncer de mama y otros modelos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Parada Cobo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Ramon Cajal Agueras Santiago<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: amparo Cano garcia <\/li>\n<li>cristina Fillat fonts (vocal)<\/li>\n<li>Antonio Bernad miana (vocal)<\/li>\n<li>Antonio Serrano hern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Parada Cobo El uso de virus modificados como agentes terap\u00e9uticos en pacientes de c\u00e1ncer es actualmente [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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