{"id":3091,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/participacion-del-receptor-de-manosa-en-la-adhesion-especifica-del-melanoma-b16-a-la-pared-sinusoidal-hepatica\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"participacion-del-receptor-de-manosa-en-la-adhesion-especifica-del-melanoma-b16-a-la-pared-sinusoidal-hepatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/participacion-del-receptor-de-manosa-en-la-adhesion-especifica-del-melanoma-b16-a-la-pared-sinusoidal-hepatica\/","title":{"rendered":"Participacion del receptor de manosa en la adhesion especifica del melanoma b16 a la pared sinusoidal hepatica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Aintzane Asumendi Mallea <\/strong><\/h2>\n<p>Dada la importancia de la adhesion tumoral al endotelio en la seleccion del lugar de implantacion metastatica, en este trabajo se profundiza en el mecanismo molecular de reconocimiento entre las celulas tumorales y el endotelio sinusoidal hepatico. Los resultados obtenidos demuestran que la formacion de metastasis hepaticas por el melanoma big esta sustancialmente condicionada por un reconocimiento molecular entre los receptores de manosa, presentes en el endotelio sinusoidal hepatico, y los oligosacaridos ricos en manosa de la superficie tumoral.  todo ello esta respaldado por las siguientes aportaciones: a) los receptores de manosa se localizan en los segmentos sinusidales donde inician su formacion las metastasis hepaticas del melanoma big y otros tumores. B) el incremento en la adhesion tumoral al e.S.H. Activado por la il-i, esta determinado en un 60%. Por el receptor endotelial de manosa, cuya expresion aumenta significativamente bajo la influencia de la il-1. C) el incremento en la densidad de residuos de manosa sobre la superficie del melanoma big, mediante dmm (un inhibidor de la manosidasa-alfa tipo i), conlleva un aumento en su adhesion al endotelio sinusoidal hepatico, que esta condicionado en un 68%. Por la expresion de manosa d) el melanoma big aumenta significativamente su rendimiento metastatico en el higado de ratones tratados con il-i, o cuando ha sido tratado con dmm antes de ser inoculado.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Participacion del receptor de manosa en la adhesion especifica del melanoma b16 a la pared sinusoidal hepatica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Participacion del receptor de manosa en la adhesion especifica del melanoma b16 a la pared sinusoidal hepatica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Aintzane Asumendi Mallea <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Vidal Vanaclocha<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Campos Mu\u00f1oz <\/li>\n<li>Juan Rod\u00e9s Teixidor (vocal)<\/li>\n<li>Senen Vilar\u00f3 Coma (vocal)<\/li>\n<li>Federico Garrido Torres-puchol (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Aintzane Asumendi Mallea Dada la importancia de la adhesion tumoral al endotelio en la seleccion del lugar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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