{"id":30952,"date":"2018-03-09T09:24:47","date_gmt":"2018-03-09T09:24:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/osteodistrofia-renal-en-pacientes-en-dialisis-peritoneal-lesion-osea-adinamica\/"},"modified":"2018-03-09T09:24:47","modified_gmt":"2018-03-09T09:24:47","slug":"osteodistrofia-renal-en-pacientes-en-dialisis-peritoneal-lesion-osea-adinamica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/osteodistrofia-renal-en-pacientes-en-dialisis-peritoneal-lesion-osea-adinamica\/","title":{"rendered":"Osteodistrofia renal  en pacientes en di\u00e1lisis peritoneal: lesi\u00f3n \u00f3sea adin\u00e1mica"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  S\u00e1nchez Gonz\u00e1lez M. Carmen <\/strong><\/h2>\n<p>La osteodistrofia renal (odr) es uno de los grandes desaf\u00eda para la nefrolog\u00eda, debido a la gran morbi-mortalidad que ocasiona a los pacientes con insuficiencia renal cr\u00f3nica y por las lagunas existentes en cuanto a su fisiopatolog\u00eda, diagn\u00f3stico, prevenci\u00f3n y tratamiento. Este desconocimiento es a\u00fan mayor en el campo de la di\u00e1lisis peritoneal (dp) y en relaci\u00f3n a la lesi\u00f3n \u00f3sea adin\u00e1mica (loa).  en este trabajo, hemos investigado los aspectos epidemiol\u00f3gicos de la odr en dp y la utilidad diagn\u00f3stica de la pth y de la biopsia \u00f3sea (ob). Dado que las \u00faltimas investigaciones otorgan un papel fundamental a los mecanismos celulares-locales del remodelado \u00f3seo, hemos investigado las diferencias en el comportamiento en cultivos, de osteoblastos procedentes de pacientes con distinto tipo de odr (bajo y alto remodelado \u00f3seo (aro). Se realiz\u00f3 un estudio con bo simult\u00e1nea (una para el cultivo y otra para el estudio histol\u00f3gico) a pacientes en di\u00e1lisis. Finalmente, quisimos observar la influencia en la evoluci\u00f3n del metabolismo \u00f3seo del tratamiento con dos soluciones de l\u00edquido peritoneal multic\u00e9ntrico, prospectivo y aleatorizado, con la realizaci\u00f3n de dos bo secuenciales (basal y a los 12 de meses).  encontramos que la loa es la forma m\u00e1s prevalente (60%) de odr en los pacientes en dp. La aparici\u00f3n de loa se asoci\u00f3 en la presencia de dm y de mayor edad (p menor 0,025). Niveles de pth mayor 450 pg\/ml predijeron una lesi\u00f3n de aro con una especificidad (e) del 100% y un valor predictivo positivo (vpp) del 100%. Una cifras de pth menor 150 pg\/ml, predijeron una loa con una sensibilidad del 91,6%, una e del 95,2% y un vpp del 97%.  respecto a los cultivos, observamos que los osteoblastos procedentes de pacientes con aro, la tasa de proliferaci\u00f3n fue superior con respecto a los pacientes con loa, lo cual indica que la proliferaci\u00f3n celular est\u00e1 relacionada con el remodelado \u00f3seo en pacientes en di\u00e1lisis. Adem\u00e1s, los<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Osteodistrofia renal  en pacientes en di\u00e1lisis peritoneal: lesi\u00f3n \u00f3sea adin\u00e1mica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Osteodistrofia renal  en pacientes en di\u00e1lisis peritoneal: lesi\u00f3n \u00f3sea adin\u00e1mica <\/li>\n<li><strong>Autor:<\/strong>\u00a0  S\u00e1nchez Gonz\u00e1lez M. Carmen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Selgas Gutierrez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Arnalich fern\u00e1ndez <\/li>\n<li>pedro Esbrit arg\u00ed\u00bcelles (vocal)<\/li>\n<li>agust\u00edn Montero Garc\u00eda (vocal)<\/li>\n<li>teresa Gonz\u00e1lez alvarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de S\u00e1nchez Gonz\u00e1lez M. Carmen La osteodistrofia renal (odr) es uno de los grandes desaf\u00eda para la nefrolog\u00eda, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[86672,824,58239,86671,86670,86673],"class_list":["post-30952","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-agustin-montero-garcia","tag-francisco-arnalich-fernandez","tag-pedro-esbrit-argielles","tag-rafael-selgas-gutierrez","tag-sanchez-gonzalez-m-carmen","tag-teresa-gonzalez-alvarez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30952","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=30952"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/30952\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=30952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=30952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=30952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}