{"id":30953,"date":"2018-03-09T09:24:47","date_gmt":"2018-03-09T09:24:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/senalizacion-coestimuladora-mediada-por-el-regulador-de-complemento-crry-p65-en-linfocitos-th2\/"},"modified":"2018-03-09T09:24:47","modified_gmt":"2018-03-09T09:24:47","slug":"senalizacion-coestimuladora-mediada-por-el-regulador-de-complemento-crry-p65-en-linfocitos-th2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/senalizacion-coestimuladora-mediada-por-el-regulador-de-complemento-crry-p65-en-linfocitos-th2\/","title":{"rendered":"Se\u00f1alizaci\u00f3n coestimuladora mediada por el regulador de complemento crry\/p65 en linfocitos th2"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Arturo Jim\u00e9nez Peri\u00e1\u00f1ez <\/strong><\/h2>\n<p>Crry\/p65 es una glicoprote\u00edna de tipo i perteneciente a la familia de prote\u00ednas reguladoras de la activaci\u00f3n del complemento, y la m\u00e1xima responsable de la protecci\u00f3n de las c\u00e9lulas t de rat\u00f3n frente al ataque del complemento aut\u00f3logo. Previamente este laboratorio mostr\u00f3 que crry coestimula linfocitos t cd4+ de rat\u00f3n in vitro, incrementando la proliferaci\u00f3n y secreci\u00f3n de il4 y dirigiendo el desarrollo hacia fenotipo th2.  hemos analizado la se\u00f1alizaci\u00f3n intracelular mediada a trav\u00e9s de crry en la l\u00ednea celular th2 sr.D10. La coestimulaci\u00f3n por crry incrementa la se\u00f1alizaci\u00f3n disparada por el tcr incluyendo la fosforilaci\u00f3n de p56lkc, zap-40, vav-1 y akt, as\u00ed como la inducci\u00f3n de la polimerizaci\u00f3n de actina y la activaci\u00f3n de la mapk erk dependientes de p!3k. Crry tambi\u00e9n incrementa la ruta jnk dependiente de coestimulaci\u00f3n, pero no la de la mapk p38. Estas se\u00f1ales incrementan la respuesta efectora de las c\u00e9lulas sr.D10 de fenotipo th2 aumentando la producci\u00f3n de il4 e il5, no as\u00ed la de il10 en las condiciones empleadas. Adem\u00e1s una fracci\u00f3n de crry colocaliza  con gm-1 y est\u00e1 presente en la fracci\u00f3n insoluble en detergentes no i\u00f3nicos (digs). La uni\u00f3n de crry por un anticuerpo monoclonal espec\u00edfico incrementa la presencia de crry en los digs , y la coestimulaci\u00f3n por crry induce la agregaci\u00f3n de rafts lip\u00eddicos y la polimerizaci\u00f3n de actina en los puntos de activaci\u00f3n, incrementando la presencia de cd3e u p56lkc fosforilada en los rafts.  para analizar el papel del dominio citoplasm\u00e1tico de crry, no requerido para su funci\u00f3n reguladora de complemento, hemos generado c\u00e9lulas th2 deficientes en crry, que han sido transfectadas con prote\u00ednas completas o deleccionadas en su dominio citoplasm\u00e1tico. La mutaci\u00f3n de delecci\u00f3n no afecta significativamente su efecto sobre la fosforilaci\u00f3n de p86lck, zap-70, akt, vav-1 o erk. Al igual que las formas completas, las formas truncadas de crry inducen la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Se\u00f1alizaci\u00f3n coestimuladora mediada por el regulador de complemento crry\/p65 en linfocitos th2<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Se\u00f1alizaci\u00f3n coestimuladora mediada por el regulador de complemento crry\/p65 en linfocitos th2 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Arturo Jim\u00e9nez Peri\u00e1\u00f1ez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pilar Portol\u00e9s P\u00e9rez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  monica De la fuente del rey <\/li>\n<li>Miguel angel Rodriguez marcos (vocal)<\/li>\n<li>Santiago Rodriguez de cordoba (vocal)<\/li>\n<li>Jos\u00e9 ramon Regueiro  gonzalez barros (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Arturo Jim\u00e9nez Peri\u00e1\u00f1ez Crry\/p65 es una glicoprote\u00edna de tipo i perteneciente a la familia de prote\u00ednas reguladoras [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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