{"id":31243,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inmunosupresion-con-fk506-tacrolimus-en-el-trasplante-hepatico-humano\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"inmunosupresion-con-fk506-tacrolimus-en-el-trasplante-hepatico-humano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/inmunosupresion-con-fk506-tacrolimus-en-el-trasplante-hepatico-humano\/","title":{"rendered":"Inmunosupresion con fk506 (tacrolimus) en el trasplante hepatico humano."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Andreu Edo Cots <\/strong><\/h2>\n<p>Fk506 (tacrolimus) es un macrolido inmunosupresor que inhibe la sintesis de il-2 y otras citoquinas, evitando la activacion de los linfocitos t. La experiencia clinica hasta el momento habia demostrado su potente accion inmunosupresora pero tambien, la aparicion de importante toxicidad relacionada con las dosis elevadas y la via e.V.. El objetivo del presente estudio es evaluar una nueva forma de administracion con fk506 basada en dosis bajas y por via oral desde el postrasplante inmediato junto con corticoides. Se han incluido un total de 26 pacientes y se ha analizado su evolucion postoperatoria y durante el seguimiento de un a\u00f1o. Este grupo de pacientes (grupo de estudio) se ha comparado con un grupo previo (grupo control) tratados segun un regimen habitual con ciclosporina y corticoides. Fk506 ha demostrado un alto grado de eficacia (rechazo agudo fk506 36% vs cya 57.6%; rechazo cronico 0% vs 19.2%) manteniendo unos indices de toxicidad aceptables (hipertension fk506 28% vs cya 42.3%; diabetes 48% vs 38.4%; nefrotoxicidad 16% vs 38.4%; neurotoxicidad 72% vs 46.1%). No ha sido necesaria la utilizacion de la via e.V. En ningun caso y la suspension de los corticoides ha sido posible en un 40% de los pacientes.  nuestra experiencia confirma la aplicabilidad de esta nueva forma de tratamiento con fk506.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inmunosupresion con fk506 (tacrolimus) en el trasplante hepatico humano.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inmunosupresion con fk506 (tacrolimus) en el trasplante hepatico humano. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Andreu Edo Cots <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Margarit Creixell<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel Armengol Carrasco <\/li>\n<li>Joan Figueras Felip (vocal)<\/li>\n<li>Jos\u00e9 Bonnin Bonnin (vocal)<\/li>\n<li>Rafael Ma\u00f1ez Mendiluce (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Andreu Edo Cots Fk506 (tacrolimus) es un macrolido inmunosupresor que inhibe la sintesis de il-2 y otras [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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