{"id":31248,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-clinica-de-la-caracterizacion-genotipica-del-carcinoma-de-celula-no-pequena-basado-en-la-mutacion-de-los-genes-k-ras\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"implicacion-clinica-de-la-caracterizacion-genotipica-del-carcinoma-de-celula-no-pequena-basado-en-la-mutacion-de-los-genes-k-ras","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/implicacion-clinica-de-la-caracterizacion-genotipica-del-carcinoma-de-celula-no-pequena-basado-en-la-mutacion-de-los-genes-k-ras\/","title":{"rendered":"Implicacion clinica de la caracterizacion genotipica del carcinoma de celula no peque\u00f1a basado en la mutacion de los genes k-ras."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Romero Fenili <\/strong><\/h2>\n<p>Los objetivos de este estudio han sido determinar la incidencia y el tipo de mutaciones encontradas en el oncogen k-ras en el carcinoma de pulmon de celula no peque\u00f1a y evaluar su presencia como factor de pronostico.  fueron estudiados 192 pacientes. El adn genomico fue extraido del material tumoral y posteriormente se busco identificar las mutaciones del oncogen k-ras a traves de la tecnica del dot-blot.  fueron encontradas mutaciones en 51 pacientes (27%), siendo el 80% de ellas en el codon 12. El tiempo de supervivencia media fue de 15 meses para los pacientes sin mutacion y de 8 meses para los pacientes con mutacion. En el analisis multivariable de los factores de supervivencia, solamente el estadio de la enfermedad y la presencia de mutacion del oncogen k-ras fue significativo (p=0.00001 y p=0.04).  conclusion: la incidencia del oncogen k-ras en el cancer de pulmon de celula no peque\u00f1a es del 27%, siendo su presencia y el estadio de la enfermedad los unicos factores pronosticos significativos estadisticamente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicacion clinica de la caracterizacion genotipica del carcinoma de celula no peque\u00f1a basado en la mutacion de los genes k-ras.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicacion clinica de la caracterizacion genotipica del carcinoma de celula no peque\u00f1a basado en la mutacion de los genes k-ras. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Romero Fenili <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jaume Fern\u00e1ndez Llamazares Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pedro Quesada Marin <\/li>\n<li>Mercedes Canela Cardona (vocal)<\/li>\n<li>Mar\u00eda no Monzo Planella (vocal)<\/li>\n<li>Joan Moya Amor\u00f3s (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Romero Fenili Los objetivos de este estudio han sido determinar la incidencia y el tipo de mutaciones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,11771,347],"tags":[14217,1459,14042,87275,1458,87274],"class_list":["post-31248","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-genetica-clinica","category-oncologia-clinica","tag-jaume-fernandez-llamazares-rodriguez","tag-joan-moya-amoros","tag-maria-no-monzo-planella","tag-mercedes-canela-cardona","tag-pedro-quesada-marin","tag-romero-fenili"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/31248","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=31248"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/31248\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=31248"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=31248"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=31248"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}