{"id":31391,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/exposicion-al-plomo-en-la-infancia-en-el-area-metropolitana-de-barcelona-citotoxicidad-del-plomo-sobre-cultivos-de-fibroblastos-humanos\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"exposicion-al-plomo-en-la-infancia-en-el-area-metropolitana-de-barcelona-citotoxicidad-del-plomo-sobre-cultivos-de-fibroblastos-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/exposicion-al-plomo-en-la-infancia-en-el-area-metropolitana-de-barcelona-citotoxicidad-del-plomo-sobre-cultivos-de-fibroblastos-humanos\/","title":{"rendered":"Exposicion al plomo en la infancia en el area metropolitana de barcelona. citotoxicidad del plomo sobre cultivos de fibroblastos humanos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eduardo Sole Mir <\/strong><\/h2>\n<p>Objetivos: determinar la exposicion a pb en ni\u00f1os del area metropolitana de barcelona mediante la determinacion de plumbemia (pbs) y protoporfirina de zinc (zpp) y observar su relacion con determinados factores de riesgo (edad, sexo, zona de residencia). Valorar la utilidad de zpp como screening de intoxicacion por pb. Estudiar la toxicidad de pb sobre fibroblastos en cultivo, valorando diferentes funciones celulares.  material y metodos: determinacion de pbs mediante espectrofotometria de absorcion atomica y de zpp mediante hematofluorimetria. Relacionar los resultados con los factores de riesgo. Valorar la utilidad de zpp analizando su sensibilidad (s), especificidad (e), valores predictivos (vp), indices de verosimilitud (lr) y la curva de caracteristicas operativas para el receptor (cor). Valorar puntos finales de toxicidad de pb sobre fibroblastos: sintesis de adn, numero de celulas, actividad lisosomial y mitocondrial, contenido de atp celular y efecto del pb sobre la formacion de productos finales de lipoperoxidacion.  resultados: pbs ni\u00f1os (n=1158)=4.52+-0.94, pbs adultos (n=254) =4.78+-0.36 (diferencias ns). Se detectan diferencias significativas en pbs segun edad (1la=2.89, 1a=4.39, p&lt;0.05), sexo (ni\u00f1os=4.85, ni\u00f1as=4.13, p=0.0002), epoca del a\u00f1o (meses calidos=5.03, frios=4.39, p&lt;0.0001). No se detectan diferencias segun patolog\u00eda ni zona de residencia (urbana\/rural). PreValencia de intoxicacion (pbs 10ug\/dl): 4.2% en ni\u00f1os, 9% en adultos (p=0.01), sin diferencias segun factores de riesgo. Zpp ha mostrado una mala correlacion con pbs (r=0.098). Ningun punto de corte de zpp ha mostrado buenos valores de e, s, vp o lr. El area bajo la curva cor es 0.52, ic 95% 0.49-0.54. Los efectos toxicos celulares son progresivos con el tiempo de exposicion, y en general se atenuan con las mayores concentraciones de stf. La sintesis de adn disminuye tras 24 horas, la cantidad de proteinas celulares a partir de las 48 hora<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Exposicion al plomo en la infancia en el area metropolitana de barcelona. citotoxicidad del plomo sobre cultivos de fibroblastos humanos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Exposicion al plomo en la infancia en el area metropolitana de barcelona. citotoxicidad del plomo sobre cultivos de fibroblastos humanos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eduardo Sole Mir <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Ballabriga Aguado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Alfredo Gallart Catala <\/li>\n<li> Domingo Roig Jos\u00e9 Luis (vocal)<\/li>\n<li>LLuis Serra Majem (vocal)<\/li>\n<li>Manuel Cruz Hern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eduardo Sole Mir Objetivos: determinar la exposicion a pb en ni\u00f1os del area metropolitana de barcelona mediante [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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