{"id":31460,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-inmunogenicidad-de-la-gp63-y-su-implicacion-en-las-etapas-iniciales-de-la-infeccion-por-leishmania-infantum\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"estudio-de-la-inmunogenicidad-de-la-gp63-y-su-implicacion-en-las-etapas-iniciales-de-la-infeccion-por-leishmania-infantum","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudio-de-la-inmunogenicidad-de-la-gp63-y-su-implicacion-en-las-etapas-iniciales-de-la-infeccion-por-leishmania-infantum\/","title":{"rendered":"Estudio de la inmunogenicidad de la gp63 y su implicacion en las etapas iniciales de la infeccion por leishmania infantum."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Graciela Carrillo Rosales <\/strong><\/h2>\n<p>Durante la infeccion natural en perros la respuesta humoral frente a la gp63 esta restringida a la region carboxilo terminal de la proteina y es predominantemente de tipo th1. Esta proteina, ademas, esta implicada en los procesos de union y entrada del parasito a la celula hospedadora. La implicacion se demuestra mediante la utilizacion de diferentes anticuerpos especificos para la gp63, capaces de bloquear tanto la union como la entrada del parasito.  utilizando tanto la proteina completa como fragmentos de la misma, es posible inducir en animales inmunizados con estos antigenos, una respuesta inmune capaz de reducir la parasitosis en el modelo de infeccion en ratones. Esta reduccion es de hasta cuatro ordenes de magnitud con respecto a los controles no vacunados. La respuesta inmune asociada a esta reduccion, contrariamente a lo esperado, no es ni predominantemente th1 ni th2.  la inmunizacion de animales de experimentacion con fragmentos solapantes de la proteina demuestra la importancia de la conformacion en la inmunogenicidad de un determinado epitope.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la inmunogenicidad de la gp63 y su implicacion en las etapas iniciales de la infeccion por leishmania infantum.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la inmunogenicidad de la gp63 y su implicacion en las etapas iniciales de la infeccion por leishmania infantum. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Graciela Carrillo Rosales <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gracia Morales Kucharski<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Fernando Valdivieso Amate <\/li>\n<li>Vicente Larraga Rodr\u00edguez De Vera (vocal)<\/li>\n<li>Ignacio Navarrete L\u00f3pez-c\u00f3zar (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Graciela Carrillo Rosales Durante la infeccion natural en perros la respuesta humoral frente a la gp63 esta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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