{"id":3154,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/contribucion-al-estudio-de-la-funcion-suprarrenal-bajo-terapia-con-corticoides-inhalados-en-el-asma-infantil\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"contribucion-al-estudio-de-la-funcion-suprarrenal-bajo-terapia-con-corticoides-inhalados-en-el-asma-infantil","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/contribucion-al-estudio-de-la-funcion-suprarrenal-bajo-terapia-con-corticoides-inhalados-en-el-asma-infantil\/","title":{"rendered":"Contribucion al estudio de la funcion suprarrenal bajo terapia con corticoides inhalados en el asma infantil"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eduardo Gonz\u00e1lez P\u00e9rez-yarza <\/strong><\/h2>\n<p>Objetivo. Estudiar el funcionalismo del eje hipotalamo-hipofisis-suprarrenal en ni\u00f1os asmaticos tratados con corticoides inhalados (ci) de forma continua a largo plazo y validar los metodos de estudio.  dise\u00f1o. Estudio abierto, observacional.  ambito del estudio. Consulta externa de la seccion de neumolog\u00eda pediatrica del hospital aranzazu de san sebastian.  sujetos de estudio. Ni\u00f1os entre 3 y 14 a\u00f1os de edad, de ambos sexos:  muestra a, n=108, tratados con budesonida inhalada (dosis media 1.352+-405ug\/1,73m2\/dia) durante 329+-148 dias.  muestra b, n=108, poblacion normal.  muestra c, n=116, tratados con ci (dosis media 1.187+-238 ug\/1,73m2\/dia) durante 518+-262 dias.  determinaciones.  muestra a, test de estimulacion con acth iv, determinado acth, actividad de renina plasmatica (arp), aldosterona y cortisol basales; cortisol y aldosterona post-estimulacion 30 y 60 minutos.  muestra b, cortisol libre en orina de 24 horas (clo).  muestra c, clo. Si el clo era inferior a -1 ds, test de estimulacion con acth, midiendo cortisol basal, 30 y 60 minutos post-estimulacion.  analisis estadistico. Descriptiva, test de mann-whitney, anova y regresion lineal. Nivel de significacion 5%.  resultados.  muestra a, acth y arp basales normales.  cortisol basal inferior a 165 nmol-l, 11 casos sin correlacion con tiempo y\/o dosis. Test de acth: cortisol patologico en 10 casos con correlacion con la dosis administrada; aldosterona, normal.  muestra b. Clo en poblacion normal 81,98+-32,12 nmol\/m2\/dia sin diferencias entre sexos (p=0,08).  muestra c, clo 69,75+-35,04 nmol\/m2\/dia con test de acth (n=30) normal.  conclusiones. Los valores basales en suero de cortisol y acth, no son validos para el control evolutivo de los posibles efectos secundarios de los ci. La medida de aldosterona en el test de acth no es de utilidad. Se han obtenido los valores normales de clo en ni\u00f1os. El tratamiento con ci disminuye la excreccion de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Contribucion al estudio de la funcion suprarrenal bajo terapia con corticoides inhalados en el asma infantil<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Contribucion al estudio de la funcion suprarrenal bajo terapia con corticoides inhalados en el asma infantil <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eduardo Gonz\u00e1lez P\u00e9rez-yarza <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfonso Delgado Rubio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel Bueno Sanchez <\/li>\n<li>Jos\u00e9 Mar\u00eda Martinon Sanchez (vocal)<\/li>\n<li>Miguel Garcia Fuentes (vocal)<\/li>\n<li> Lozano De La Torre M. Jos\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eduardo Gonz\u00e1lez P\u00e9rez-yarza Objetivo. Estudiar el funcionalismo del eje hipotalamo-hipofisis-suprarrenal en ni\u00f1os asmaticos tratados con corticoides inhalados [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,69,139,12909,161],"tags":[12926,13258,13259,13260,2521,10555],"class_list":["post-3154","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-enfermedades-pulmonares","category-medicina-interna","category-pais-vasco-euskal-herriko-unibertsitatea","category-pediatria","tag-alfonso-delgado-rubio","tag-eduardo-gonzalez-perez-yarza","tag-jose-maria-martinon-sanchez","tag-lozano-de-la-torre-m-jose","tag-manuel-bueno-sanchez","tag-miguel-garcia-fuentes"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/3154","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=3154"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/3154\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=3154"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=3154"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=3154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}