{"id":31542,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/propranolol-mas-prazosina-versus-propranolol-mas-5-mononitrato-de-isosorbida-en-el-tratamiento-de-la-hipertension-portal\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"propranolol-mas-prazosina-versus-propranolol-mas-5-mononitrato-de-isosorbida-en-el-tratamiento-de-la-hipertension-portal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/propranolol-mas-prazosina-versus-propranolol-mas-5-mononitrato-de-isosorbida-en-el-tratamiento-de-la-hipertension-portal\/","title":{"rendered":"Propranolol mas prazosina versus propranolol mas 5-mononitrato de isosorbida en el tratamiento de la hipertension portal."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jeronimo Iborra Herrera <\/strong><\/h2>\n<p>La hipertension portal se define por un aumento patologico del gradiente de presion entre la vena porta y la vena cava. La consecuencia fundamental del desarrollo de hipertension portal es la formacion de varices esofagicas, con el consiguiente riesgo de rotura, que constituye la principal causa de muerte en los pacientes con cirrosis hepatica. La aplicabilidad del tratamiento farmacologico se basa en la idea de que una reduccion mantenida de la presion hidrostatica en el territorio portal, se traduciria en una significativa disminucion de la presion variceal y por tanto del riesgo de rotura. El objetivo primordial del tratamiento farmacologico es conseguir una respuesta hemodinamicamente significativa o bien una reduccion de mas de un 20% sobre los valores basales o preferiblemente disminuir el gradiente de presion portal en valores absolutos por debajo de 12 mmhg, pues su consecucion supone alcanzar el nivel necesario para la prevencion del sangrado variceal. Los objetivos de este estudio han sido comparar en pacientes con cirrosis hepatica e hipertension portal los efectos en la hemodinamica esplacnica y sistemica de la combinacion de propranolol mas prazosina frente a propranolol mas 5-mononitrato de isosorbida (5-mis).  nuestra hipotesis de trabajo fue considerar que la asociacion propranolol mas prazosina era mas eficaz que propranolol mas 5-mis en cuanto a conseguir una reduccion clinicamente significativa de la presion portal. Para ello se ha realizado un estudio prospectivo y aleatorizado en 56 pacientes cirroticos con hipertension portal y varices esofagicas demostradas endoscopicamente.  en todos los pacientes se realizo un estudio hemodinamico basal en el que se analizaron parametros de la hemodinamica esplacnica (gradiente de presion portal y flujo sanguineo hepatico), sistemica (gasto cardiaco, tension arterial, frecuencia cardiaca, presiones cardiopulmonares), pruebas cuantitativas de funcion hepatica (aclaramient<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Propranolol mas prazosina versus propranolol mas 5-mononitrato de isosorbida en el tratamiento de la hipertension portal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Propranolol mas prazosina versus propranolol mas 5-mononitrato de isosorbida en el tratamiento de la hipertension portal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jeronimo Iborra Herrera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Agust\u00edn Albillos Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Abueu Garcia Luis Esteban <\/li>\n<li>Luis Manzano Espinosa (vocal)<\/li>\n<li>Rafael Ba\u00f1ares Ca\u00f1izares (vocal)<\/li>\n<li>Valentin Cuernas-mons Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jeronimo Iborra Herrera La hipertension portal se define por un aumento patologico del gradiente de presion entre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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