{"id":31593,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/accion-de-la-vitronectina-durante-la-diferenciacion-de-neuronas-de-proyeccion-del-sistema-nervioso-central-del-pollo\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"accion-de-la-vitronectina-durante-la-diferenciacion-de-neuronas-de-proyeccion-del-sistema-nervioso-central-del-pollo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/accion-de-la-vitronectina-durante-la-diferenciacion-de-neuronas-de-proyeccion-del-sistema-nervioso-central-del-pollo\/","title":{"rendered":"Accion de la vitronectina durante la diferenciacion de neuronas de proyeccion del sistema nervioso central del pollo."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Martinez Morales Juan  Ramon <\/strong><\/h2>\n<p>Los numerosos estudios que analizan el linaje de las celulas neuroepiteliales del sistema nervioso central (snc) de los vertebrados demuestran que, en la mayor parte de los casos, dichos precursores neurales son pluripotentes hasta poco tiempo antes de que el nacimiento neuronal se produzca. La determinacion fenotipica de estos precursores debe estar influenciada por tanto por la actividad de factores presentes en el microambiente que los rodea. En el presente trabajo se identifica uno de estos inductores selectivos de la diferenciacion neuronal: la vitronectina, una glicoproteina de la matriz extracelular.  se emplean como modelos de estudio del snc la retina y la medula espinal del embrion de pollo, donde se detecta la presencia tanto de la vitronectina como de sus receptores integrinicos durante estadios del desarrollo coincidentes con la diferenciacion neuronal. Asi mismo, el estudio de la distribucion del mensajero de la glicoproteina mediante hibridacion in situ demuestra que son las propias celulas neuroepiteliales las responsables de sintetizar la vitronectina presente en su microambiente.  los resultados obtenidos en el presente trabajo indican que la vitronectina presente en el snc induce selectivamente la diferenciacion de ciertos fenotipos neuronales. Asi, la neutralizacion de la vitronectina endogena mediante anticuerpos bloqueantes de su actividad inhibe tanto en explantes tisulares como in vivo la generacion de celulas ganglionares en la retina y motoneuronas en el tubo neural, sin afectar aparentemente la generacion de otros tipos neuronales.  consecuentemente, la adicion de vitronectina soluble a explantes de retina o tubo neural induce la generacion de celulas ganglionares y motoneuronas respectivamente.  finalmente, se demuestra en explantes de tubo neural que el morfogeno sonic hedgehog, cuya actividad inductora de la diferenciacion de las neuronas motoras ha sido descrita en otros trabajos, requiere de la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Accion de la vitronectina durante la diferenciacion de neuronas de proyeccion del sistema nervioso central del pollo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Accion de la vitronectina durante la diferenciacion de neuronas de proyeccion del sistema nervioso central del pollo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Martinez Morales Juan  Ramon <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfredo Rodriguez Tebar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Avila De Grado <\/li>\n<li>Ignacio Torres Aleman (vocal)<\/li>\n<li>Luis Puelles Lopez (vocal)<\/li>\n<li>Inmaculada Canal Beltran (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Martinez Morales Juan Ramon Los numerosos estudios que analizan el linaje de las celulas neuroepiteliales del sistema [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,17],"tags":[29564,6465,56805,3041,1823,87927],"class_list":["post-31593","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-alfredo-rodriguez-tebar","tag-ignacio-torres-aleman","tag-inmaculada-canal-beltran","tag-jesus-avila-de-grado","tag-luis-puelles-lopez","tag-Martinez-morales-juan-ramon"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/31593","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=31593"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/31593\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=31593"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=31593"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=31593"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}